POMEGRANATEFRUITEXTRACT Chemische Eigenschaften,Einsatz,Produktion Methoden
Anticancer Research
Pomegranate fruit extract (PFE) downregulated the proteins involved in cell cycleregulation during G1 phase (Gullett et al. 2010). Moreover it inhibited growth,progression and angiogenesis of tumour by suppressing MAP kinase pathway,mTOR and NF-κB signalling pathway in the animal model for primary lung tumour(Khan and Mukhtar 2015) and urothelial carcinoma (Song et al. 2013). The MAPK/ERK pathway conducts a signal for sustained growth of tumour. Unrestrainedgrowth is an essential step for the advancement of all cancers. In many cancers (e.g.melanoma), a flaw in the MAP/ERK pathway heads to the uncontrolled growth.Many compounds can obstruct steps in the MAP/ERK pathway and therefore arepossible drugs for the treatment of cancer (De Luca et al. 2012; Vicinanza et al.2013). Pro-apoptotic Bak and Bax are overexpressed, while anti-apoptotic Bcl-XLand Bcl2 are downregulated by administration of PFE, triggering apoptosis (Hausmann et al. 2014). Furthermore, apoptosis might be induced by activation ofpro-caspase 12 by dysregulated valosin-containing protein triggered by PFE (Derryet al. 2014).
POMEGRANATEFRUITEXTRACT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
