[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)
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- CAS-Nr.
- 741713-40-6
- Englisch Name:
- [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)
- Synonyma:
- R547;CS-238;Ro 4584820;R547 ，S2688;R547(Ro 4584820);R547 >=98% (HPLC);R547, 10 mM in DMSO;R547 Ro-4584820 R-547;3-difluoro-6-Methoxyphenyl)-;[4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2
- CBNumber:
- CB41562444
- Summenformel:
- C18H21F2N5O4S
- Molgewicht:
- 441.45
- MOL-Datei:
- 741713-40-6.mol
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[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) Eigenschaften
- Siedepunkt:
- 703.7±70.0 °C(Predicted)
- Dichte
- 1.49
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- crystalline solid
- pka
- 4.22±0.10(Predicted)
- Farbe
- White to off-white
- InChI
- InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)
- InChIKey
- JRNJNYBQQYBCLE-UHFFFAOYSA-N
- SMILES
- C(C1=CN=C(NC2CCN(S(C)(=O)=O)CC2)N=C1N)(C1=C(OC)C=CC(F)=C1F)=O
Sicherheit
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cyclin-dependent kinases (Cdks) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. R547 is a diaminopyrimidine compound that inhibits Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1 (K
is = 1-3 nM). It is inactive against a panel of more than 120 unrelated kinases (K
is > 5 μM). R547 inhibits tumor cell proliferation (IC
50s ≤ 0.6 μM
in vitro), inducing cell cycle arrest at G
1 and G
2 phases and apoptosis as well as reducing phosphorylation of the retinoblastoma protein. It also demonstrates antitumor activity
in vivo in various human tumor xenograft models.
[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 132)Lieferanten
741713-40-6()Verwandte Suche:
- [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)
- [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
- Ro 4584820
- [4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2
- 3-difluoro-6-Methoxyphenyl)-
- R547(Ro 4584820)
- 5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine
- (4-Amino-2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-5-pyrimidinyl)(2,3-difluoro-6-methoxyphenyl)methanone
- (4-Amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphen
- CS-238
- Methanone, [4-amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)-
- R547 >=98% (HPLC)
- [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) USP/EP/BP
- R547 Ro-4584820 R-547
- R547, 10 mM in DMSO
- R547 ，S2688
- R547
- 741713-40-6
- C18H21F2N5O4S
- Inhibitors
