BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
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- CAS-Nr.
- 935693-62-2
- Englisch Name:
- BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
- Synonyma:
- CS-207;BIX 01294;BIX01294,BIX-01294;BIX 01294 (free base);EZSolution? BIX 01294;BIX-01294, 10 mM in DMSO;BIX-01294;BIX 01294; BIX01294;BIX 01294 hydrate trihydrochloride;Histone Lysine methyltransferase Inhibitor;BIX 01294, histone methyltransferase inhibitor
- CBNumber:
- CB42095439
- Summenformel:
- C28H38N6O2
- Molgewicht:
- 490.64
- MOL-Datei:
- 935693-62-2.mol
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BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Eigenschaften
- Siedepunkt:
- 654.6±65.0 °C(Predicted)
- Dichte
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
- pka
- 9.34±0.70(Predicted)
- Aggregatzustand
- Off-white solid
- Farbe
- Off-white
- Wasserl?slichkeit
- H2O: >20mg/mL
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
- InChIKey
- BZOWJAYUMMHCDW-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(OC)C(OC)=C2)=C(NC2CCN(CC3=CC=CC=C3)CC2)N=C1N1CCCN(C)CC1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable diazepinyl-quinazolinamine, non-SAM (S-adenosylmethionine) analog-based HMTase (histone methyltransferase) inhibitor that selectively interferes with the G9a-catalyzed H3K9me2 (histone H3 Lys9 dimethylation) modification (IC
50 = 1.7 μM) in a reversible manner. It inhibits the GLP-catalyzed H3K9me3 only at much higher concentrartions (IC
50 = 38 μM) and exhibits little activity against H3 methylations catalyzed by other HMTases (PRMT1, SET7/9, ESET, SUV39H1). Shown to effectively synergize with
Oct3/4 and
Klf4 in inducing reprogramming of primary murine fetal NPCs (Neural Progenitor Cells) into iPS (induced Pluripotent Stem) cells without additional viral transduction of
Sox2 and c-
Myc.
Biologische Aktivit?t
G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor (IC 50 values are 0.7 and 1.7 μ M respectively) that displays no activity at other HTMases up to 37 μ M. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro .
BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 153)Lieferanten
935693-62-2()Verwandte Suche:
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride
- BIX 01294
- BIX 01294 hydrate trihydrochloride
- BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
- 4-QuinazolinaMine, 2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-
- 2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-4-quinazolinaMine hydrate trihydrochloride
- BIX 01294 (free base)
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
- Histone Lysine methyltransferase Inhibitor
- BIX-01294;BIX 01294; BIX01294
- N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trih
- BIX01294,BIX-01294
- CS-207
- Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem
- N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine
- 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quina
- EZSolution? BIX 01294
- 2-(Hexahydro-4-Methyl-1H-1,4-Diazaze-1-Yl)-6,7-Dimethoxy-N-[1-(Phenylmethyl)-4-Piperidyl]-4-Quinazoline Amine
- BIX 01294, histone methyltransferase inhibitor
- BIX-01294, 10 mM in DMSO
- 935693-62-2
- C28H41Cl3N6O2
- C28H38N6O23HCl
- C28H38N6O2
- C28H43Cl3N6O3
- Epigenetics
- G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor.
