2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
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- CAS-Nr.
- 304896-28-4
- Englisch Name:
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
- Synonyma:
- AGK2;CS-2248;SIRT,AGK2;AGK2 ，S7577;AGK2;AGK-2;AGK 2;AGK2, 10 mM in DMSO;SIRT2 Inhibitor, AGK2;AGK2, sirtuin2 (SIRT2) inhibitor;SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide
- CBNumber:
- CB42101251
- Summenformel:
- C23H13Cl2N3O2
- Molgewicht:
- 434.27
- MOL-Datei:
- 304896-28-4.mol
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2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Eigenschaften
- Siedepunkt:
- 675.1±55.0 °C(Predicted)
- Dichte
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: soluble2mg/mL, clear (warmed)
- Aggregatzustand
- Yellow solid
- pka
- 8.87±0.43(Predicted)
- Farbe
- White to Yellow to Orange
- InChI
- 1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
- InChIKey
- SVENPFFEMUOOGK-SDNWHVSQSA-N
- SMILES
- Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36:Reizt die Augen.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
Biologische Aktivit?t
Selective inhibitor of SIRT2 (IC 50 = 3.5 μ M). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μ M. Reduces α -synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
Biochem/physiol Actions
AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 147)Lieferanten
304896-28-4()Verwandte Suche:
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
- AGK2
- SIRT2 Inhibitor, AGK2
- 2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide
- SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem
- CS-2248
- AGK2;AGK-2;AGK 2
- 2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide USP/EP/BP
- SIRT,AGK2
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide
- AGK2, sirtuin2 (SIRT2) inhibitor
- 2-Cyano-3-[5-(2,5-dichloro-phenyl)-furan-2-yl]-N-quinolin-5-yl-acrylamide/AGK2
- AGK2, 10 mM in DMSO
- AGK2 ，S7577
- 304896-28-4
- C23H13Cl2N3O2AgK2
- C23H13Cl2N3O2
- Inhibitors
