3,6-dibromopyrazin-2-amine
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- CAS-Nr.
- 957230-70-5
- Englisch Name:
- 3,6-dibromopyrazin-2-amine
- Synonyma:
- 2-aMino-3,6-DibroMopyrazine;3,6-DIBROMOPYRAZIN-2-AMINE;3,6-dibromo-2-pyrazinamine;3,6-didroMopyrazin-2-aMine;2,5-Dibromo-3-aminopyrazine;3,6-Dibromopyrazine-2-amine;3-Amino-2,5-dibromopyrazine;2-Pyrazinamine, 3,6-dibromo-;3,6-Dibromopyrazin-2-ylamine;3,6-DIBROMOPYRAZIN-2-AMIN...
- CBNumber:
- CB42455291
- Summenformel:
- C4H3Br2N3
- Molgewicht:
- 252.89
- MOL-Datei:
- 957230-70-5.mol
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3,6-dibromopyrazin-2-amine Eigenschaften
- Siedepunkt:
- 314℃
- Dichte
- 2.287
- Flammpunkt:
- 144℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.05±0.10(Predicted)
- Aussehen
- Light brown to light yellow Solid
- Wasserl?slichkeit
- Slightly soluble in water.
- InChI
- InChI=1S/C4H3Br2N3/c5-2-1-8-3(6)4(7)9-2/h1H,(H2,7,9)
- InChIKey
- ZEDFFSRZLCREEN-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Br)=CN=C1Br
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
3,6-dibromopyrazin-2-amine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
It is used as a pharmaceutical intermediate.
Synthese
Diphenylphosphoryl azide (488 mg, 1.77 mmol) and triethylamine (180 mg, 1.77 mmol) were added to a solution of the acid (500 mg, 1.77 mmol) in tert-butanol (12 mL). The reaction mixture was stirred at reflux for 18 h and then quenched with water. The volatiles were removed under reduced pressure. The residue was dissolved in 4:1 TFA/DCM (5 mL) and stirred at rt for 1 h. The volatiles were removed under reduced pressure. The residue was dissolved in DCM and washed with 1N aq. NaOH. The combined organic extracts were dried (Na2SO4), filtered and concentrated. The crude residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient to afford 3,6-dibromopyrazin-2-amine 120 mg (27%) of bromoanisol as a colorless oil. MS m/z (ES): 253 (M+H)+.
3,6-dibromopyrazin-2-amine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3,6-dibromopyrazin-2-amine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 116)Lieferanten
- 3,6-DIBROMOPYRAZIN-2-AMINE
- 3,6-DIBROMOPYRAZIN-2-AMIN...
- 3,6-Dibromopyrazin-2-ylamine
- 3,6-Dibromopyrazine-2-amine
- 2,5-Dibromo-3-aminopyrazine
- 3,6-didroMopyrazin-2-aMine
- 3-Amino-2,5-dibromopyrazine
- 3,6-dibromo-2-pyrazinamine
- 2-Pyrazinamine, 3,6-dibromo-
- 2-aMino-3,6-DibroMopyrazine
- 957230-70-5
