NS 1738
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- CAS-Nr.
- 501684-93-1
- Englisch Name:
- NS 1738
- Synonyma:
- NS 1738;NSC 213859;NS 1738 (NSC 213859);NS 1738, 10 mM in DMSO;1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea;N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea;Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-;NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
- CBNumber:
- CB42455756
- Summenformel:
- C14H9Cl2F3N2O2
- Molgewicht:
- 365.13
- MOL-Datei:
- 501684-93-1.mol
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NS 1738 Eigenschaften
- Siedepunkt:
- 344.1±42.0 °C(Predicted)
- Dichte
- 1.617±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- White crystalline solid.
- pka
- 8.08±0.13(Predicted)
- Farbe
- Off-White to Light Grey
- InChI
- 1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
- InChIKey
- OUDXRNQPVSMGDW-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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NS 1738 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC
50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
Verwenden
NS 1738 is a selective a7 nAchR allosteric modulator.
Biologische Aktivit?t
Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .
NS 1738 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NS 1738 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 85)Lieferanten
- NS 1738
- N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
- NSC 213859
- 1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea
- Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-
- NS 1738 (NSC 213859)
- NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
- NS 1738, 10 mM in DMSO
- 501684-93-1
