SU 16f

251356-45-3

CAS-Nr.: 251356-45-3

Englisch Name:: SU 16f

Synonyma:: SU 16f;SU16f, 10 mM in DMSO;PDGFR Tyrosine Kinase Inhibitor VII;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-;3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid

CBNumber:: CB42501833

Summenformel:: C24H22N2O3

Molgewicht:: 386.44

MOL-Datei:: 251356-45-3.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 76

SU 16f Eigenschaften

Siedepunkt:: 661.7±55.0 °C(Predicted)

Dichte: 1.292±0.06 g/cm3(Predicted)

storage temp.: Store at RT

L?slichkeit: Soluble to 100 mM in DMSO

Aggregatzustand: Dark orange solid

pka: 4+-.0.10(Predicted)

Farbe: Yellow to orange

InChI: 1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13-

InChIKey: APYYTEJNOZQZNA-MOSHPQCFSA-N

Sicherheit

WGK Germany	WGK 1
Speicherklasse	11 - Combustible Solids

SU 16f Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.

Allgemeine Beschreibung

A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC₅₀ = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC₅₀ = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC₅₀ = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC₅₀ = 10 μM).

SU 16f Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SU 16f Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30224	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+86-0086-13720134139	orders@jknbiochem.com	China	5221	58
Shaanxi Dideu New Materials Co. Ltd	18192503167	1036@dideu.com	China	12683	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15838	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4865	55

5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
SU 16f
PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
SU16f, 10 mM in DMSO
PDGFR Tyrosine Kinase Inhibitor VII
251356-45-3
Angiogenesis and Metastasis

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