GLYX 13
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- CAS-Nr.
- 117928-94-6
- Englisch Name:
- GLYX 13
- Synonyma:
- Rapastinel;GLYX 13;GIYX-13;CS-1640;TPPT-amide;GLYX 13 TFA;UNII-6A1X56B95E;NRX-1074 GLYX-13;GLYX13(Rapastinel);Rapastinel(GLYX-13)
- CBNumber:
- CB42518800
- Summenformel:
- C18H31N5O6
- Molgewicht:
- 413.47
- MOL-Datei:
- 117928-94-6.mol
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GLYX 13 Eigenschaften
- Siedepunkt:
- 844.2±65.0 °C(Predicted)
- Dichte
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
- pka
- 12.26±0.45(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to tan
- Wasserl?slichkeit
- Soluble to 2 mg/ml in water
- Sequenz
- Thr-Pro-Pro-Thr-NH2
- InChIKey
- GIBQQARAXHVEGD-BSOLPCOYSA-N
- SMILES
- C(N)(=O)[C@H]([C@H](O)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](O)C)N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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GLYX 13 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
Biochem/physiol Actions
GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.
GLYX 13 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GLYX 13 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 159)Lieferanten
- L-ThreoninaMide, L-threonyl-L-prolyl-L-prolyl-
- GLYX-13 trifluoroacetate
- L-Threonyl-L-prolyl-L-prolyl-L-threoninamide trifluoroacetate
- GLYX 13
- Thr-Pro-Pro-Thr-NH2 trifluoroacetate
- TPPT-amide trifluoroacetate
- GIYX-13
- L-Threonyl-L-prolyl-L-prolyl-L-threoninamide
- GLYX-13 trifluoroacetate,Rapastinel
- GLYX13(Rapastinel)
- (S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide
- CS-1640
- GLYX-13;GLYX 13;GLYX13
- Rapastinel(GLYX-13)
- UNII-6A1X56B95E
- Rapastinel,GLYX-13,Thr-Pro-Pro-Thr-NH2, >99%
- GLYX-13;GLYX13;GLYX 13;THR-PRO-PRO-THR-NH2
- Thr-Pro-Pro-Thr-NH2
- TPPT-amide
- (2s)-1-[(2s)-1-[(2s,3r)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
- (S)-1-(L-threonyl-L-prolyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)pyrrolidine-2-carboxamide
- NRX-1074 GLYX-13
- Rapastinel (GLYX-13) acetate
- GLYX 13 TFA
- Rapastinel，GLYX-13，Thr-Pro-Pro-Thr-NH2
- Rapastinel
- 117928-94-6
- C18H31N5O6
