Edoxaban hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Edoxaban (Lixiana), a direct inhibitor of Factor Xa (FXa) was approved by the Minister of Health, Labor, and Welfare in Japan in April 2011 for the prevention of venous thromboembolism (VTE) after major orthopedic surgery. Edoxaban inhibits hFXa with a Ki=0.56 nM. Edoxaban is a weak inhibitor of thrombin Ki=6000 nM, has >10,000 fold selectivity over other serine proteases in the coagulation cascade, and demonstrates selectivity over trypsin and chymotrypsin. The synthesis of this class of FXa inhibitors begins with assembly of the diaminocyclohexane scaffold, cis-t-butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate. The free amine is coupled to the P1 group, 2-((5-chloropyridin-2-yl) amino)-2-oxoacetic acid. The Boc protecting group on the amine of the scaffold is removed and the resulting free amine is coupled to the P4 group, 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid.

Originator

Daiichi Pharmaceutical (Japan)

Trademarks

Lixiana

Edoxaban hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Edoxaban hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19956	58
SPIRO PHARMA		eric_feng1954@126.com	China	9248	55
Amatek Scientific Co. Ltd.	0512-56316828	info@amateksci.com	China	28769	58
Nanjing crow LuNing pharmaceutical technology co., LTD	13382066392		CHINA	4877	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24957	58
Zhengzhou Converging Chemical Co. LTD	0371-53399770 18037166334	3857571523@qq.com	China	6693	58
Xibiao (Shanghai) Technology Co., Ltd	18512111473 18512111473	2238774038@qq.com	China	3148	58

---

• Edoxaban hydrochloride
• N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide hydrochloride
• Edoxaban (HCl salt)
• Edoxaban Monohydrochloride
• Edoxaban Hcl
• N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide:hydrochloride
• 480448-29-1
• C24H30ClN7O4SHCl