SC 66
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- CAS-Nr.
- 871361-88-5
- Englisch Name:
- SC 66
- Synonyma:
- SC 66;CS-2480;SC66;SC 66;SC66, 10 mM in DMSO;SC-66, Allosteric Akt inhibitor;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA;(2-E,6-E)-2,6-di(4-pyridylmethylene)cyclohexylone;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
- CBNumber:
- CB42565930
- Summenformel:
- C18H16N2O
- Molgewicht:
- 276.33
- MOL-Datei:
- 871361-88-5.mol
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SC 66 Eigenschaften
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: ≥5mg/mL (warmed)
- Aggregatzustand
- powder
- Farbe
- faint yellow to dark yellow
- InChI
- 1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
- InChIKey
- CYVVJSKZRBZHAV-UNZYHPAISA-N
- SMILES
- O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
13 - Non Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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SC 66 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-
associated phosphatidylinositol-
3,4,5-
trisphosphate (PIP
3) or phosphatidylinositol-
3,4-
bisphosphate (PIP
2). Increased Akt activity,
e.g., through a gain-
of-
function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-
mediated deactivation. SC-
66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-
66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-
of-
function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-
66 (15 mg/kg) suppresses tumor growth.
Verwenden
SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.
SC 66 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SC 66 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 116)Lieferanten
- SC 66
- Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
- CS-2480
- SC66;SC 66
- (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone
- Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
- 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
- SC-66, Allosteric Akt inhibitor
- SC66, 10 mM in DMSO
- (2-E,6-E)-2,6-di(4-pyridylmethylene)cyclohexylone
- 871361-88-5
