(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride

177943-33-8

CAS-Nr.: 177943-33-8

Englisch Name:: (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride

Synonyma:: PF-04859989HCl;PF-04859989 HCl;PF04859989 hydrochloride;PF-4859989 hydrochloride;PF-04859989 hydrochloride;PF-04859989 HCl, 10 mM in DMSO;PF-04859989 hydrochloride >=98% (HPLC);(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride

CBNumber:: CB42598844

Summenformel:: C9H11ClN2O2

Molgewicht:: 214.64884

MOL-Datei:: 177943-33-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 32

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Eigenschaften

storage temp.: room temp

L?slichkeit: H2O: soluble20mg/mL, clear

Aggregatzustand: powder

Farbe: white to beige

Wasserl?slichkeit: Water: 22 mg/ml

InChI: 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1

InChIKey: WZOBDOKCHIUXAY-FJXQXJEOSA-N

SMILES: N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 32)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29974	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	4976	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847 13636370518	shyysw007@163.com	China	89686	60
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	29660	68

(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
PF04859989 hydrochloride
PF-04859989 hydrochloride
PF-4859989 hydrochloride
PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
PF-04859989 hydrochloride >=98% (HPLC)
2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
PF-04859989 HCl
PF-04859989HCl
disorders,schizophrenia,Inhibitor,inhibit,PF04859989 HCl,midbrain,psychiatric,PF 04859989 HCl,dopamine,neurons,cognitive ,impairment
PF-04859989 HCl, 10 mM in DMSO
177943-33-8

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