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Omadacycline

Omadacycline Struktur
389139-89-3
CAS-Nr.
389139-89-3
Englisch Name:
Omadacycline
Synonyma:
OMadacycline;AMadacycline;PTK-796;PTK 0796;Odacicycline;Omadacycline-D9;2H9]-Omadacycline;Omadacycline (PTK 0796;Omadacycline Impurity 60;Omadacycline, 10 mM in DMSO
CBNumber:
CB42627315
Summenformel:
C29H40N4O7
Molgewicht:
556.65
MOL-Datei:
389139-89-3.mol

Omadacycline Eigenschaften

Siedepunkt:
837.6±65.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:1.0(Max Conc. mg/mL);1.8(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
4.50±1.00(Predicted)
Farbe
Yellow to orange
Stabilit?t:
Hygroscopic
InChIKey
JEECQCWWSTZDCK-IQZGDKDPSA-N
SMILES
C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(CNCC(C)(C)C)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  WGK 3
Speicherklasse 11 - Combustible Solids
Hazard Classifications Lact.
Repr. 2
Bildanzeige (GHS) Exclamation Mark (GHS07)Health Hazard (GHS08)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Omadacycline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Omadacycline, the drug that US FDA approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It is not susceptible to common tetracycline-resistancemechanisms, and has demonstrated efficacy against a broad spectrum of pathogens including resistant isolates, which are increasing in prevalence and complexity.

Verwenden

Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).

Pharmakologie

Omadacycline has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections.The in vitro activity of Omadacycline against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 g/ml against Bacteroides spp, 0.5 g/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica,1 g/ml against Peptostreptococcus spp, and 16 g/ml against Clostridium perfringens.

Nebenwirkungen

OMadacycline may cause serious adverse reactions including hypersensitivity reactions, tooth discoloration,Clostridioides difficile-associated diarrhea, and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.Common adverse reactions include nausea, vomiting, infusion site reactions, alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl transferase increased, hypertension, headache, diarrhea, insomnia, and constipation.Mild to moderate nausea and vomiting were the most frequent treatment-emergent adverse events in omadacycline (111 [30%] of 368 and 62 [17%] of 368, respectively) groups.

Omadacycline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Omadacycline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 113)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ShenZhen H&D Pharmaceutical Technology Co., LTD
+8618627948422
sale@hdimpurity.com China 3681 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com CHINA 954 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30224 58
Dideu Industries Group Limited
+86-86-15536356810 +8617392712697
1022@dideu.com China 28757 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39039 58
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490
info@gihichemicals.com China 49952 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58

389139-89-3()Verwandte Suche:


  • PTK 0796
  • PTK-796
  • OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE
  • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
  • Omadacycline-D9
  • AMadacycline
  • OMadacycline
  • Amadacycline,Omadacycline,PTK 0796
  • 2H9]-Omadacycline
  • Omadacycline (PTK 0796
  • spectrum,antibacterial,pathogens,Omadacycline,synthesis,Inhibitor,urinary,community-acquired,PTK-0796,skin-structure,anaerobic,acute,protein,pneumonia,tetracycline,inhibit,skin,Gram-negative,atypical,Antibiotic,Gram-positive,tract,PTK0796,broad,Bacterial,infections,agent
  • (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • Omadacycline, 10 mM in DMSO
  • Omadacycline Impurity 60
  • Odacicycline
  • 389139-89-3
  • C29H40N4O7
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