一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

7,10-Dimethoxy-10-DAB III

7,10-Dimethoxy-10-DAB III Struktur
183133-94-0
CAS-Nr.
183133-94-0
Englisch Name:
7,10-Dimethoxy-10-DAB III
Synonyma:
12a;Cabazitaxel Impurity;11S;12S;(2aR;4]benz[1;11-dihydroxy-4;6-dimethoxy-4a;7,10-MeO-10-DAB;Cabazitaxel IMP
CBNumber:
CB42630016
Summenformel:
C31H40O10
Molgewicht:
572.64
MOL-Datei:
183133-94-0.mol

7,10-Dimethoxy-10-DAB III Eigenschaften

Schmelzpunkt:
>225°C (dec.)
Siedepunkt:
675.8±55.0 °C(Predicted)
Dichte
1.31
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMF (Slightly, Heated, Sonicated), DMSO (Very Slightly, Heated), Methanol
pka
12.82±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Optische Rotation
-27.00°(C=0.01g/mL, DMF, 589nm)
Stabilit?t:
Hygroscopic
InChIKey
MGJMLMORVVDLIU-VHLOTGQHSA-N
SMILES
O1C[C@@]2(OC(C)=O)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](O)C4)[C@@H](OC)C(=O)[C@]3(C)[C@@H](OC)C[C@@]12[H]

Sicherheit

HS Code  29329990

7,10-Dimethoxy-10-DAB III Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cabazitaxel is a kind of Second line Drug for the treatment of prostate cancer, FDA Priority Review status approval listing is obtained because its curative effect is remarkable, for the advanced prostate cancer patients to the invalid even aggravation of Docetaxel, the first-selected medicine being used for the treatment of late period, hormone antagonist type prostate cancer.7,10-dimethoxy-10-Dab III is the important intermediate preparing Cabazitaxel.

Verwenden

4-Deacetyl-4-propionyl Cabazitaxel is an impurity of Cabazitaxel (C046500).A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.

Synthese

Solvent is methylene dichloride, and alkali is the two dimethylamino naphthalene of 1,8-, and the mol ratio of 10-deacetylate Bakating III and trimethylammonium oxygen Tetrafluoroboric acid is 1:35; The mol ratio of 10-deacetylate Bakating III and alkali is 1:45;By 10-Dab (10g, 18.4mmol) be dissolved in methylene dichloride (200ml), add 1, the two dimethylamino naphthalene (177.2g of 8-, 828mmol), stirring at room temperature half an hour, add trimethylammonium oxygen Tetrafluoroboric acid (95.2g, 643.4mmol) again, stirring at room temperature 20h, suction filtration reaction solution, filter cake methylene dichloride washes 3 times, collects filtrate, and after concentrated, column chromatography (chloroform: methyl alcohol=100:3) obtains 7,10-dimethoxy-10Dab III 4.6g, yield 43.7%.

7,10-Dimethoxy-10-DAB III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


7,10-Dimethoxy-10-DAB III Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 196)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 880 50
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21586 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Jiangsu Yew Pharmaceutical Co., Ltd.
+86-510-66865338 +86-189-2133-5032 @
junwenjiang@live.cn CHINA 30 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
Shanghai Yingrui Biopharma Co.,Ltd
21-33585366
export01@shyrchem.com CHINA 1319 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9636 58

  • 7β,10β-diMethoxy-10-deacetylbaccatin III
  • Cabazitaxel interMediate 1
  • 7,10-MeO-10-DAB
  • 7β,10β-Dimethoxy-10-dabⅢ
  • 7β,10β-diMethoxy-10-DAB-II
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxe
  • 7,1-DiMethoxy-1-DAB III
  • 2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-diMethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-Methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
  • 7,10-Dimethoxy-10-DAB III (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
  • 4-Deacetyl-4-propionyl Cabazitaxel
  • Cabazitaxel Impurity 17
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
  • 7,10-Dimethoxy-10-DAB III
  • 10-Deacetyl-7,10-dimethoxy-Baccatin III
  • Cabazitaxel intermediate
  • Cabazitaxel IMP
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-oneChemicalBook
  • (2aR
  • 11-dihydroxy-4
  • 11-methano-5H-cyclodeca[3
  • 11S
  • 12b-dodecahydro-9
  • 12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1
  • 12S
  • 13-tetramethyl-7
  • 2-b]oxet-5-oneChemicalBook
  • 4]benz[1
  • 6-dimethoxy-4a
  • (2aR,4S,4aS,6R,9S,11S,12S,12
  • Cabazitaxel Deacyl Impurity
  • Cabazitaxel Initiator 1 impurity A
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12
  • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
  • Cabazitaxel lmpurities
  • 4,6-Dimethoxy Baccatin III
  • 7β,10β-dimethoxy-10-DAB-III
  • (2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-di...
  • 183133-94-0 7, 10-Dimethoxy-10-DAB III
  • 7,10-dimethoxy -10-DAB
  • 7,10-dimethoxy-Baccatin III
  • 10-Dimethoxy-10-DAB III
  • (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,15-dihydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-on
  • 7,10-dimethoxy-Baccatin
  • 7β,10β-Dimethyl-10-deacetylbaccatinIII
  • 7,10-Dimethoxy-10-DA
  • (4R,5S)-5-((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-12-(benzoyloxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl) 3-tert-butyl 2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate
  • (4R,5S)-5-((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-12-(benzoyloxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca
  • 12a
  • Cabazitaxel Impurity
  • 183133-94-0
  • API
  • Intermediates
  • 183133-94-0
Copyright 2019 ? ChemicalBook. All rights reserved
新民市| 二连浩特市| 清镇市| 北辰区| 毕节市| 苗栗县| 三亚市| 彩票| 南陵县| 揭西县| 鲁甸县| 两当县| 弥渡县| 朝阳区| 丰原市| 屏边| 永德县| 莎车县| 社旗县| 康保县| 叙永县| 尚志市| 兴海县| 佳木斯市| 昆明市| 石家庄市| 乐山市| 兴安县| 米泉市| 新源县| 泾源县| 翁源县| 临湘市| 德江县| 响水县| 安阳县| 定陶县| 定兴县| 寻甸| 潮州市| 尼勒克县|