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Terlipressin

Terlipressin acetate Struktur
14636-12-5
CAS-Nr.
14636-12-5
Bezeichnung:
Terlipressin
Englisch Name:
Terlipressin acetate
Synonyma:
TERLIPRESSIN;Terlipressin for NMR identification;H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2;Glypressin;Glycylpressin;Terilipressin;TerlipressinuM;Terlipressin CRS;Terlipressin(net);Terlipressin, >99%
CBNumber:
CB4266213
Summenformel:
C52H74N16O15S2
Molgewicht:
1227.37
MOL-Datei:
14636-12-5.mol

Terlipressin Eigenschaften

Schmelzpunkt:
>170°C (dec.)
Siedepunkt:
1824.0±65.0 °C(Predicted)
Dichte
1.46±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
9.90±0.15(Predicted)
Farbe
White
Sequenz
Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2,(Disulfide bridge: Cys-Cys)
InChIKey
BENFXAYNYRLAIU-ITQMCZIINA-N
CAS Datenbank
14636-12-5(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  3504009000
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung P261, P271, P304+P340, P312
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P312 Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Terlipressin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Terlipressin acetate is a novel synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. After the action of aminopeptidase in the body, after removing the three glycyl residues at its N-terminus, it slowly "releases" the active lysine vasopressin. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.

Chemische Eigenschaften

N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin (Terlipressin acetate) is White Solid

Verwenden

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It is used norepinephrine-resistant septic shock and hepatorenal syndrome. It is also used in the treatment of acute variceal bleeding. Terlipressin Acetate 1 mg solution for injection is used for the treatment of: bleeding from dilated (widening) veins in the food pipe leading to your stomach (called bleeding oesophageal varices).

Nebenwirkungen

In clinical trials, the most common side effects of terlipressin administration were paleness, increased blood pressure, peripheral ischemia, abdominal pain, nausea, diarrhea, and headache.
Terlipressin related adverse events are common and most of terlipressin related adverse events were mild or moderate, which can be resolved spontaneously without any intervention. As terlipressin acts mainly on the splanchnic vessels, the incidence of severe ischemic complications is lower with terlipressin than with vasopressin. However, it may cause serious complications such as myocardial infarction, intestinal ischemia, peripheral cyanosis, and skin necrosis[1].

Terlipressin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Terlipressin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 451)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 995 58
Apextide Co Ltd
+8615300650552
info@apextide.com China 91 58
Chengdu Shengnuo Biopharm Co.,Ltd
+8613880038419
leili@snbiopharm.com China 70 58
Jinan Hong Kongda Chemical Co.,LTD
+86-18753193522 +86-18753193522
sales@hkdchem.com China 97 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533
Brad@rongnabiotech.com China 3365 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58
henan kanbei chemical co.,ltd
+undefined-86-1523780-4566 +undefined15237804566
henankanbeichemical@163.com China 511 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971
deasea125996@gmail.com China 2472 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58

14636-12-5(Terlipressin)Verwandte Suche:


  • [N-α-Triglycyl-8-lysine]-vasopressin
  • 130: PN: WO2010033207 SEQID: 171 claiMed protein
  • 1-Triglycyl-8-lysine Vasopressin
  • Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin
  • Nα-Glycyl-glycyl-glycyl-lysine-vasopressin
  • Nα-Glycylglycylglycyl-vasopressin
  • Nα-Gly-Gly-Gly-8-Lys-vasopressin
  • Triglycyl-8-lysine-vasopressin
  • TerlipressinuM
  • Terlipressin acetate, >=98%
  • Terlipressin Diacetate Salt
  • Thymosin al Acetate
  • TERLIPRESSIN ACETATE
  • Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9)
  • (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide
  • N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
  • N-(GLYCYLGLYCYLGLYCYL)-8-L-LYSINE-VASOPRESSIN
  • H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond)
  • Glypressin
  • L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-N-(Gly-Gly-Gly-)-NH2
  • Glycylpressin
  • Gly-Gly-Gly-[Lys8]vasopressin
  • Gly-Gly-Gly-L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-NH2
  • Terilipressin
  • Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
  • Terlipressin, Terlipressine, Terlipressina, Terlipressinum
  • H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH(Disulfide bond)
  • Terlipressin Acetate salt
  • Terlipressin, >99%
  • (2S)-N-[6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-19-[[2-[[2-[(2-amino-1-oxoethyl)amino]-1-oxoethyl]amino]-1-oxoethyl]amino]-10-(3-amino
  • Terlipressin CRS
  • Vasopressin, N-(glycylglycylglycyl)-8-L-lysine-
  • N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin USP/EP/BP
  • TerlipressinuM Glycylpressin
  • N-α-Triglycyl-8-lysine]-vasopressin
  • Terlipressin-15N3-13C6
  • TerlipressinQ: What is Terlipressin Q: What is the CAS Number of Terlipressin Q: What is the storage condition of Terlipressin Q: What are the applications of Terlipressin
  • Thymosin α1 Acetate 14636-12-5
  • Terlipressin(net)
  • L-α-amino-n-Butyric acid
  • H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
  • Terlipressin for NMR identification
  • N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin /Terlipressin Acetate
  • TERLIPRESSIN
  • 14636-12-5
  • 146363-12-5
  • 156-1-3
  • C52H74N16O15S2
  • C52H74N16O15S2C2H4O2
  • hormones
  • Peptide
  • Amino Acid Derivatives
  • 14636-12-5
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