LDE-225 Diphosphate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sonidegib phosphate (XXIX),
an orally bioavailable, small molecule smoothened (SMO)
receptor antagonist developed by Novartis, was approved in
2015 in Switzerland, the U.S., and the EU for the treatment of
adult patients with advanced or locally advanced basal cell
carcinoma (BCC). BCC is the most frequently diagnosed
skin cancer, constituting 80% of all nonmelanoma skin
cancers. While most BCCs can be treated through surgery
or radiation therapy, some patients (<10%) have more
advanced tumors for which surgery may be contraindicated
or impractical; treatment options for these patients are limited.
SMO, a G-protein coupled receptor-like protein (GPCR), is a
key regulator in the hedgehog (Hh) pathway, which is activated
in a number of tumors including BCC. In a multicenter
clinical trial for sonidegib, an objective response rate of 43%
was observed for patients with locally advanced BCC (dosing at
200 mg once daily), with sustained clinically meaningful
responses based on an 18-month analysis. Sonidegib joins
vismodegib as marketable treatments of BCC. Vismodegib,
which was approved in 2012 as a first-in-class SMO receptor
antagonist, represented the first Hedgehog signaling pathway
targeting agent to gain FDA approval.
Verwenden
NVP-LDE225 Diphosphate Salt is a potent, selective, and orally bioavailable Smoothened (Hedgehog Signaling Pathway) antagonist.
Definition
ChEBI: A phosphate salt obtained by reaction sonidegib with two equivalent of phosphoric acid. Used for treatment of locally advanced basal cell carcinoma.
LDE-225 Diphosphate Upstream-Materialien And Downstream Produkte
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