Lafutidine
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- CAS-Nr.
- 118288-08-7
- Englisch Name:
- Lafutidine
- Synonyma:
- Stogar;LACTITOL;frg-8813;Protecadin;LAFUTIDINE;Laflutidine;Lafurtidine;118288-08-07;enyl)acetamide;Lafutidine API
- CBNumber:
- CB4297653
- Summenformel:
- C22H29N3O4S
- Molgewicht:
- 431.55
- MOL-Datei:
- 118288-08-7.mol
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Lafutidine Eigenschaften
- Schmelzpunkt:
- 92.7-94.9°
- Siedepunkt:
- 704.2±60.0 °C(Predicted)
- Dichte
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Wasserl?slichkeit
- Insoluble in water
- L?slichkeit
- DMF:5.0(Max Conc. mg/mL);11.59(Max Conc. mM)
DMSO:48.67(Max Conc. mg/mL);112.77(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:10):0.09(Max Conc. mg/mL);0.21(Max Conc. mM)
Ethanol:9.0(Max Conc. mg/mL);20.86(Max Conc. mM)
- Aggregatzustand
- powder to crystal
- pka
- 13.13±0.46(Predicted)
- Farbe
- White to Orange to Green
- InChI
- 1S/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-
- InChIKey
- KMZQAVXSMUKBPD-DJWKRKHSSA-N
- SMILES
- C(NC/C=C\COC1=NC=CC(CN2CCCCC2)=C1)(=O)CS(CC1=CC=CO1)=O
- CAS Datenbank
- 118288-08-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| WGK Germany |
WGK 1 |
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| HS Code |
29349990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Lafutidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Lafutidine was launched in Japan for the treatment of gastritis, reflux oesophagitis and
peptic ulcers. It can be prepared in eight steps from 4-(2-tetrahydropyranyloxy)-2(Z)-butenl-
ol. Lafutidine is a potent and longer-acting H
2 antagonist compared to other marketed
compounds of its class such as cimetidine and famotidine. In contrast to other
commercially available H
2 antagonists, lafutidine also exerts a gastroprotective action
probably via capsaicin-sensitive afferent nerves. It was clinically effective in the treatment
of nonsteroidal antiinflammatory drug-induced ulcer in patients refractory to existing
antiulcer agents.
Verwenden
Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion
Lafutidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lafutidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 331)Lieferanten
118288-08-7()Verwandte Suche:
- n-(4-(4-piperidinylmethyl)pyridyl-2-oxy)butenyl-2-(furfurylsulfinyl)acetamide
- 2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide
- (Z)-2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide
- Adefovir Dipivioxil
- (Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)
- (Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-
- LAFUTIDINE(SUBJECTTOPATENTFREE)
- 118288-08-07
- LACTITOL
- 2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide
- Laflutidine
- Protecadin
- Stogar
- LAFUTIDINE
- (+-)-2-(furfurylsulfinyl)-n-(4-(4-(piperidinomethyl)-2-pyridyl)oxy-(z)-2-but
- (z)-inyl)oxy)-2-butenyl)
- acetamide,2-((2-furanylmethyl)sulfinyl)-n-(4-((4-(1-piperidinylmethyl)-2-pyrid
- enyl)acetamide
- frg-8813
- 2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)4-[[4-(1-piperidinylmethyl)-2-pyridinyl] oxy]-2-butenyl]-acetamide
- 2-(2-furanylmethylsulfinyl)-N-[2-hydroxy-4-[4-(4-piperidinylmethyl)-2-pyridinyl]but-1-enyl]acetamide
- Lafutidine Lafutidine
- (Z)-2-[(Furan-2-ylmethyl)sulfinyl]-N-[4-[[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy]but-2-en-1-yl]acetamide
- Lafutidine USP/EP/BP
- 2-(furan-2-ylmethylsulfinyl)-N-[(Z)-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide
- (+)-(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide
- Lafutidine (FRG-8813)
- LafutidineQ: What is
Lafutidine Q: What is the CAS Number of
Lafutidine Q: What is the storage condition of
Lafutidine Q: What are the applications of
Lafutidine
- Lafutidine API
- R)-Palonosetron Hydrochloride
- Lafutidine Tablets
- Lafurtidine
- Lafutidine, 10 mM in DMSO
- Lafutidine (Standard)
- 118288-08-7
- 118288-89-7
- 118288-08-07
- 118288-08-1
- 18288-08-7
- C22H29N3O4S
- Other APIs
- Active Pharmaceutical Ingredients
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
