Anifostine trihydrate
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- CAS-Nr.
- 112901-68-5
- Englisch Name:
- Anifostine trihydrate
- Synonyma:
- Amifostine;AMIFOSTIN;Aminophosphorine;S-(2-((3-Aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate;WR2721;ANIFOSTINE;Ethyol trihydrate;Amifostine (150 mg);Amifostine (1019406);Anifostine trihydrate
- CBNumber:
- CB4316378
- Summenformel:
- C5H17N2O4PS
- Molgewicht:
- 232.23
- MOL-Datei:
- 112901-68-5.mol
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Anifostine trihydrate Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- PBS (pH 7.2): 5 mg/ml
- Aggregatzustand
- powder
- pka
- pKa1 <2.0; pKa2 4.2; pKa3 9.0; pKa4 11.7(at 25℃)
- Farbe
- White to off-white
- InChI
- InChI=1S/C5H15N2O3PS.H2O/c6-2-1-3-7-4-5-12-11(8,9)10;/h7H,1-6H2,(H2,8,9,10);1H2
- InChIKey
- JKOQGQFVAUAYPM-UHFFFAOYSA-N
- SMILES
- S(P(O)(O)=O)CCNCCCN.O
- CAS Datenbank
- 112901-68-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TE6491000 |
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| HS Code |
2930909165 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Anifostine trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Protectant (topical); radioprotector.
Trademarks
Ethyol (MedImmune) [USAN previously used: Ethiofos.].
Biochem/physiol Actions
Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.
Anifostine trihydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Anifostine trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 296)Lieferanten
112901-68-5()Verwandte Suche:
- Amifostine (150 mg)
- Anifostine trihydrate
- Ethanethiol,2-[(3-aMinopropyl)aMino]-, 1-(dihydrogen phosphate), hydrate (1:3)
- Amifostine trihydrate, >=98%
- Aminopropylamino)ethylsulfanylphosphonic acid trihydrate
- S-2-(3-AMINOPROPYLAMINO)ETHYL O,O-DIHYDROGEN PHOSPHOROTHIOATE
- WR2721
- Amifostinetrihydrateormonohydrate
- Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate
- Amifostine Disulfide (25 mg)
- 2-(3-aminopropylamino)ethylsulfanylphosphonic acid trihydrate
- AMINOPROPYL AMINOETHYLTHIOPHOSPHATE
- Ethyol trihydrate
- Aminopropylamino)ethylsulfanylphosphonic acid trihydrate USP/EP/BP
- ANIFOSTINE
- 2-(3-Aminopropylamino)ethylsulfanylphosphonic acid trihydrate USP/EP/BP
- Amifostine trihydrate (WR2721)
- Amifostine (1019406)
- Amifostine Disulfide (1019417)
- Amifostine
- AMIFOSTIN
- S-(2-((3-Aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate
- DNA-damage,thiol,HIF-PH,cytoprotective,Broad-spectrum,Hypoxia-inducible factors,HIF-α1,WR-2721,MDM-2/p53,Inhibitor,p53,Amifostine trihydrate,WR 2721,inhibit,antiangiogenic,radioprotector,HIF/HIF Prolyl-Hydroxylase,HIFs
- 2-(3-Amino-propylamino)ethylthiophosphonic acid,trihydrate
- Amphotericin trihydrate
- S-(2-((3-aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate hydrate
- Aminophosphorine trihydrate
- Aminophosphorine
- 112901-68-5
- 1129-68-5
- C5H15N2O3PS3H2O
- C5H21N2O6PS
- Cancer Research
- Antitumor Agents
- BioChemical
- Therapy Adjuncts
- Inhibitors
- 112901-68-5
