Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat
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- CAS-Nr.
- 64953-12-4
- Bezeichnung:
- Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat
- Englisch Name:
- Latamoxef sodium
- Synonyma:
- 6059s;moxam;S 6059;ly127935;LY 12735;HY-B1484;Shiomarin;Festamoxin;FestamoxinLy;Shionogi 6059S
- CBNumber:
- CB4352372
- Summenformel:
- C20H21N6NaO9S
- Molgewicht:
- 544.47
- MOL-Datei:
- 64953-12-4.mol
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Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Eigenschaften
- Schmelzpunkt:
- >156oC (dec.)
- alpha
- D22 -45° (water)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- Methanol (Slightly)
- Aggregatzustand
- White to Pale Yellow
- Farbe
- White to off-white
- Merck
- 13,6311
- Stabilit?t:
- Unstable in solution (DMSO or Methanol)
- Major Application
- forensics and toxicology
veterinary
- InChIKey
- GRIXGZQULWMCLU-GDUWRUPCSA-L
- SMILES
- N([C@@]1(C(=O)N2C(=C(CSC3=NN=NN3C)CO[C@]12[H])C(=O)O)OC)C(=O)[C@@H](C1C=CC(O)=CC=1)C(=O)O.[NaH] |&1:1,17,26,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
42/43 |
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| S-S?tze: |
22-36/37-45 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
RN6824000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Resp. Sens. 1
Skin Sens. 1 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
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P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Latamoxef was synthesized by Shionogi Pharmaceuticals in 1975 starting with benzylpenicillin and using a novel drug design. The oxacephem nucleus, in which the sulfur atom had been replaced by oxygen, was substituted with a methoxyl group at the 7α position, as in the cephamycins. A carboxyl moiety and a hydroxybenzyl group were added at the 7β position, as in carbenicillin, and a methyltetrazolylthiomethyl group was attached at the 3 position. These substitutions resulted in a strong activity against gram-negative bacteria and a high resistance to the action of βlactamase, along with excellent activity against Pseudomonas aeruginosa, even though the compound has no activity against Staphylococcus aureus.
Verwenden
Moxalactam Sodium is an oxacephem antibiotic. Moxalactam Sodium is more effective against Escherichia coli and Pseudomonas aeruginosa than cephalosporins.
Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 235)Lieferanten
64953-12-4(Dinatrium-7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat)Verwandte Suche:
- MOXALACTAM SODIUM SALT
- 5-oxa-1-azabicyclo(4.2.o)oct-2-ene-2-carboxylicacid,7-((carboxy(4-hydroxyphen
- 6059s
- antibiotic6059-s
- disodiumlatamoxef
- latamoxefsodium
- ly127935
- moxalactamdisodium
- moxam
- moxalactam sodium
- moxalactam sodium salt, mixture of isomers
- disodium 7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, disodium salt, (6R,7R)- (9CI)
- Festamoxin
- LY 12735
- S 6059
- Shiomarin
- Shionogi 6059S
- (6R,7R)-7-[2-Carboxy-2-(p-hydroxyphenyl)acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
- 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, disodium salt
- Einecs 265-288-4
- Moxalactam Disodium (500 mg)
- 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7R)-
- (6R,7R)-7-[[(2R)-Carboxy(4-hydroxyphenyl)acetyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid DisodiuM Salt
- MoxalactaM SodiuM Salt (Mixture of diastereoMers)
- Moxalactam sodium, >=830 μg/mg
- Latamoxef Disodium
- HY-B1484
- FestamoxinLy
- Latamoxef sodium USP/EP/BP
- Latamoxef sodiumr
- Moxalactam Sodium Salt (Mixture of Diastereomers) (10mM in DMSO)
- TIANFU-CHEM CAS NO.64953-12-4 Latamoxef sodium
- Latamoxef sodium, CAS:64953-12-4
- Sodium (6R,7R)-7-((R)-2-carboxylato-2-(4-hydroxyphenyl)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- Moxalactam Sodium Salt (Latamoxef Sodium)
- (6R,7R)-7-((R)-2-carboxy-2-(4-hydroxyphenyl)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, sodium salt
- Laxocefuroxime sodium
- Moxalactam sodium salt, 10 mM in DMSO
- (6R,7R)-7-((R)-2-Carboxy-2-(4-hydroxy-phenyl)-acetcarboxcarboxcarboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid sodium salt
- 7-[[carboxy(4-hydroxyphenyl)ethylacyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]-8-oxy-5-oxy-1-azabiscyclo[4.2.0]octyl-2-ene-2-macetic acidisalt
- 64953-12-4
- 4953-12-4
- C20H18N6Na2O9S
- C20H18N6O9S2Na
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