10-Hydroxycamptothecin
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- CAS-Nr.
- 19685-09-7
- Englisch Name:
- 10-Hydroxycamptothecin
- Synonyma:
- SN38;HCPT;HYDROXYCAMPTOTHECIN;(S)-10-HYDROXYCAMPTOTHECIN;10-HCPT;10-hydroxycamptothecin,HCPT;Ampule;NSC 107124;HYDROCAMPTOTHECINE;hydroxy-camptotheci
- CBNumber:
- CB4445430
- Summenformel:
- C20H16N2O5
- Molgewicht:
- 364.35
- MOL-Datei:
- 19685-09-7.mol
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10-Hydroxycamptothecin Eigenschaften
- Schmelzpunkt:
- 265-270°C
- Siedepunkt:
- 820.7±65.0 °C(Predicted)
- Dichte
- 1.60
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- ≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
- Aggregatzustand
- powder to crystal
- pka
- 8.93±0.40(Predicted)
- Farbe
- White to Yellow to Orange
- InChI
- InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
- InChIKey
- HAWSQZCWOQZXHI-FQEVSTJZSA-N
- SMILES
- N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
- CAS Datenbank
- 19685-09-7(CAS DataBase Reference)
10-Hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-
strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-
10-
hydroxy-
Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree
C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-
10-
hydroxy-
Camptothecin has strong anti-
tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC
50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-
20 μM (S)-
10-
hydroxy-
camptothecin results in cell cycle arrest at the G
2/M phase.
Chemische Eigenschaften
Yellow Solid
Verwenden
A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
10-Hydroxycamptothecin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
10-Hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 517)Lieferanten
19685-09-7()Verwandte Suche:
- Camptothecae Acuminatae extract
- hydrate,(s)-dihydroxy
- hydroxy-camptotheci
- Hydroxycamptothencine
- (20S)-10-HYDROXYCAMPTOTHECIN 98%
- (20S)-10-Hydroxycamptothecin
- HYDROCAMPTOTHECINE
- CAMPTOTHECIN, 10-HYDROXY(SH)
- HYDROXYCAMPTOTHECIN, 10-(P)
- 10-hydroxycamptothecin (TECANS)
- 10-HYDROCAMPTOTHECIN
- Ampule
- (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- NSC 107124
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)-
- (4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
- (S)-10-Hydroxycamptothecin
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Irinotecan USP RC A
- CAMPTOTHECIN, 10-HYDROXY-
- CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA
- HYDROXYCAMPTOTHECIN, 10-
- (20S)-10-HYDROXYCAMPTOTHECIN
(20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN
(S)-10-HYDROXYCAMPTOTHECIN
- CaMptothecin IMpurity
- CaMptothecin 10-Hydroxy IMpurity
- 10-HydroxycaMptothecin, froM Taxus chinensis
- (s)-10-hydroxycamptothecinhydrate
- 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3
- 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3
- (4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
- (4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-Hydroxycamptothecin
- 10-Hydroxycamptothecine
- HYDROXYCAMPTOTHECIN, 10-(RG)
- (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
- Irinotecan Related CoMpound A
- (+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
- Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-HydroxycaMptothecin, HydroxycaMptothecine
- 10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder
- Irinotecan Impurity 12
- Irinotecan EP Impurity B
- 10-Hydroxycamptothecin 19685-09-7
- (S)-4-ethyl-4,9-dihydroxy-1H-pyrano
- 10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B)
- Fructus Camptothecae
- Hydroxycamptothecin 80-98%
- (S)-10-Hydroxycamptothecin,>98%
- (20S)-10-Hydroxycamptothecine
- Camptotheca acuminata fruit extract
- (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
- 1-Hydroxy camptothecin
- 10 hydroxy CamptothecinQ: What is
10 hydroxy Camptothecin Q: What is the CAS Number of
10 hydroxy Camptothecin Q: What is the storage condition of
10 hydroxy Camptothecin
- Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quino (1347610)
- 10-HCPT
- Irinotecan EP Impurity B (10-Hydroxy Camptothecin)
- 1,4-Benzenedicarboxylicacid,bis(6-methylethyl)ester
