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Irbesartan

Irbesartan Struktur
138402-11-6
CAS-Nr.
138402-11-6
Englisch Name:
Irbesartan
Synonyma:
AVAPRO;Lrbesartan;Irbesatan;Irbersartan;Irbesartan Impurity 1;3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one;APROVEL;CS-1097;SR-47436;Irbesarta
CBNumber:
CB4454663
Summenformel:
C25H28N6O
Molgewicht:
428.53
MOL-Datei:
138402-11-6.mol

Irbesartan Eigenschaften

Schmelzpunkt:
180-181°C
Siedepunkt:
648.6±65.0 °C(Predicted)
Dichte
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: >25mg/mL
pka
4.16±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to off-white
Merck 
14,5083
BCS Class
2
InChIKey
YOSHYTLCDANDAN-UHFFFAOYSA-N
SMILES
N1C2(CCCC2)C(=O)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C=1CCCC
CAS Datenbank
138402-11-6(CAS DataBase Reference)
EPA chemische Informationen
1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (138402-11-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 26-24/25
WGK Germany  3
RTECS-Nr. HM2950270
HS Code  29332900
Speicherklasse 11 - Combustible Solids
Giftige Stoffe Daten 138402-11-6(Hazardous Substances Data)
Bildanzeige (GHS) Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)Flame (GHS02)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Irbesartan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Avapro was launched in Germany, the UK and the US for hypertension. It can be prepared in six steps starting with cyclopentanone or in three steps from 1- aminocyclopentanecarboxylic acid ethyl ester and pentanimidic ethyl ester. Avapro is an angiotensin Ⅱ receptor antagonist that is non-competitive and selective for AT, subtypes and has no AT2 activity at postsynaptic receptors compared to presynatpic. It has no affinity for various non angiotensin Ⅱ receptor types in binding, no interaction with calcium channels or antiports, and no affinity for α1- and α2--adrenoreceptors, serotonergic receptors, muscarinic m1 and m2 or other receptors. It is as potent as saralasin but with no agonist activity and is 10 times more potent than DuP753 in rats. It is similar in efficacy to enalapril (in those with severe hypertension) and atenolol, while more effective than losartan for mild to moderate hypertension.

Chemische Eigenschaften

Crystalline Solid

Verwenden

For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of conges

Definition

ChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

Allgemeine Beschreibung

Irbesartan, 2-butyl-3-[[29-(1H-tetrazol-5-yl)[1,19-biphenyl]-4-yl]methyl]1,3-diazaspiro[4,4]non-1en-4-one (Avapro), like losartan, possesses the acidic tetrazolesystem, which most likely plays a role, similar to the acidicgroups of angiotensin II, in binding to the angiotensin II receptor.In addition, the biphenyl system that serves to separatethe tetrazole from the aliphatic nitrogen is still present.A major difference in this agent is that it does not possessthe acidic side chain. Even so, irbesartan has good affinityfor the angiotensin II receptor because of hydrogen bondingwith the carbonyl moiety of the amide system. Also, thisparticular agent does not require metabolic activation ascandesartan does.

Irbesartan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Irbesartan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 849)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co., Ltd
+8615350571055
Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-86-13131129325 +8613131129325
sales1@chuanghaibio.com China 5231 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Wuhan JiyunZen Tech Co., Ltd.
+86-18062099985
Amyjiyunzen@yeah.net China 672 58
Sinoway Industrial co., ltd.
+86-0592-5800732 +86-13806035118
xie@china-sinoway.com China 1369 58
Capot Chemical Co.,Ltd.
+8613336195806
sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2988 55

  • 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE
  • IRBESARTAN
  • BMS-186295
  • APROVEL
  • 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • 2-Isopropryl-4-methylthiazole
  • 2-butyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
  • 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
  • 2-butyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one
  • 2-Isopropryl-4-methylthiazole (Irbesartan)
  • Irbesartan (200 mg)
  • Irbesartan(Avapro)
  • 2-butyl-3-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
  • 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
  • Irbesartan Synonyms 3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
  • 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
  • 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
  • 2N-Butyl-4-spirocyclopentane-2-imidazolin-5-one hydrochloride
  • IrbesartanC25H28N6O
  • 2-N-BUTYL-4-SPIROCYCLOPENTANE-1-[(2-CYANOBIPHENYL-4-YL)METHYL]-2-IMIDAZOLIN-5-ONE
  • 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, BMS-186295, SR-47436, Aprovel, Avapro
  • IRBESARTAN/3-BYTY1-3-[P-(0-1H-TETRAZOL-5-Y1-PHENY1)BENZY1],3-DIAZOSPIRO[4,4]NON-1-EN-4-KETONE
  • 2-N-BUTYL-4-SPIROCYCLOPENTANE-1-[(2-CYANOBIPHENYL-4-YL)METHYL]-2-IMIDAZOLIN-5-ONE(IRBESARTAN)
  • 2-buty1-3-[p-(0-1H-tetrazol-5-y1-pheny1)benzy1]1,3-diazospiro[4,4]non-1-en-4-ketone
  • 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-
  • 2-BUTYL-3-[2''-(1H-TETRAZOL-5-YL)BIPHENYL-4-YLMETHYL]1,3-DIAZA-SPIRO[4.4]NON-1-EN-4-ONE
  • 2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-
  • Irbesarta
  • 2-Butyl-3-[[2’-(1H-tetrazol-5-y1)[1,l'-biphenyl]-4-y1]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
  • SR-47436
  • CS-1097
  • AVAPRO; SR-47436; BMS-186295
  • ebeisaotan
  • 2-butyl-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
  • Irbesartan (SR-47436
  • Irbesartan, 99%, a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist
  • Irbesartan Control
  • Irbesartan>
  • Irbesartan CRS
  • Irbesartan USP/EP/BP
  • Irbesartan (1347700)
  • 3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
  • Irbesartan Impurity 1
  • IRBESARTAN 50% GRANULES
  • Irbesartan 2-Butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3- diazaspiro[4.4]non-1-en-4-one
  • Irbesartan Reference Standard
  • 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
  • Irbesartan (Standard)
  • Irbesartan in methanol
  • Irbesartan, 10 mM in DMSO
  • IRBESARTAN DRUG SUBSTANCE
  • IRBESARTAN USP
  • IRBESARTAN USP (NON-STERILE DRUG SUBSTANCE)
  • Irbesartan - Bio-X ?
  • 2-butyl-3-[[2'-(2H-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]nonyl-1-ene-4one
  • AVAPRO
  • Irbersartan
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