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POMALIDOMIDE-PEG2-CO2H

POMALIDOMIDE-PEG2-CO2H Struktur
2140807-17-4
CAS-Nr.
2140807-17-4
Englisch Name:
POMALIDOMIDE-PEG2-CO2H
Synonyma:
Poma-PEG2-COOH;Pomalidomide-PEG2-COOH;NUN 07174;Pomalidomide-PEG2-Acid;POMALIDOMIDE-PEG2-CO2H;Pomalidomide 4'-PEG2-acid;Thalidomide-4-NH-PEG2-COOH;Thalidomide-NH-PEG2-C2-COOH;Pomalidomide-PEG2-CO2H >=98%;Thalidomide-4-NH-PEG2-C2-COOH
CBNumber:
CB44744117
Summenformel:
C20H23N3O8
Molgewicht:
433.41
MOL-Datei:
2140807-17-4.mol

POMALIDOMIDE-PEG2-CO2H Eigenschaften

Siedepunkt:
744.6±60.0 °C(Predicted)
Dichte
1.456±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Aggregatzustand
powder or crystals
pka
4.28±0.10(Predicted)
Farbe
White to yellow
InChI
1S/C20H23N3O8/c24-15-5-4-14(18(27)22-15)23-19(28)12-2-1-3-13(17(12)20(23)29)21-7-9-31-11-10-30-8-6-16(25)26/h1-3,14,21H,4-11H2,(H,25,26)(H,22,24,27)
InChIKey
NKISJPXMSOQWER-UHFFFAOYSA-N
SMILES
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCC(O)=O)=O)NC1=O

Sicherheit

WGK Germany  WGK 3
Speicherklasse 11 - Combustible Solids

POMALIDOMIDE-PEG2-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG2-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG2-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


POMALIDOMIDE-PEG2-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
CR Corporation Limited
+8613062833949
fred.wen@crcorporation.cn China 8645 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8615965530500
nickzhang@hangyubiotech.com China 9949 58
Zhengzhou Lingzhiyue Technology Co., Ltd
+86-0371-55074660 +86-13523716970
Lingzhiyue@aliyun.com China 3145 58
Nanjing Bicbiotechnology Co., Ltd
+86-2552131256 +86-18251840740
sales@bicbiotech.com China 5994 58
Xian confluore Biological Technology Co., Ltd.
+86-15680926068
1924344760@confluore.cn China 2997 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865
han_yajun@dctc.daicel.com China 7676 65
ChemShuttle, Inc. 0510-83588313-811 18800520310
sales@chemshuttle.com China 2999 62
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860
anhua.mao@aladdin-e.com China 29974 65

  • POMALIDOMIDE-PEG2-CO2H
  • Pomalidomide-PEG2-CO2H >=98%
  • NUN 07174
  • Thalidomide-4-NH-PEG2-COOH
  • Thalidomide-NH-PEG2-C2-COOH
  • Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-
  • 3-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]propanoic Acid
  • Thalidomide-4-NH-PEG2-C2-COOH
  • 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic Acid
  • Pomalidomide-PEG2-Acid
  • 3-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]propanoic acid
  • Pomalidomide 4'-PEG2-acid
  • Pomalidomide-PEG2-CO2H
  • Pomalidomide-PEG2-COOH
  • Poma-PEG2-COOH
  • 2140807-17-4
  • APIs
  • peg
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