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Trimipramin

TRIMIPRAMINE Struktur
739-71-9
CAS-Nr.
739-71-9
Bezeichnung:
Trimipramin
Englisch Name:
TRIMIPRAMINE
Synonyma:
7162rp;il6001;7162 RP;FI 6120;IL 6001;RP-7162;Stangyl;Sapilent;Surmontil;Rhotrimine
CBNumber:
CB4490399
Summenformel:
C20H26N2
Molgewicht:
294.43
MOL-Datei:
739-71-9.mol

Trimipramin Eigenschaften

Schmelzpunkt:
45°
Siedepunkt:
426.2°C (rough estimate)
Dichte
0.9912 (rough estimate)
Brechungsindex
1.6450 (estimate)
Flammpunkt:
9℃
storage temp. 
2-8°C
pka
pKa 8.0 (Uncertain)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T
R-S?tze: 11-23/24/25-39/23/24/25
S-S?tze: 16-36/37-45
RIDADR  3249
WGK Germany  1
HazardClass  6.1(b)
PackingGroup  III
Toxizit?t LD50 oral in mouse: 250mg/kg
Bildanzeige (GHS) Flame (GHS02)Skull and Crossbones (GHS06)Health Hazard (GHS08)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Sch?digt die Organe. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.

Trimipramin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Antidepressant.

Definition

ChEBI: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant.

Weltgesundheitsorganisation (WHO)

Trimipramine, a tricyclic antidepressant was introduced in 1961 for the management of endogenous depression. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.

Pharmakokinetik

Trimipramine is one of the antidepressants with the most pronounced differences in pharmacokinetics caused by the CYP2D6 genetic polymorphism. Its bioavailability and systemic clearance depended significantly on the CYP2D6 isoform with a linear dose relationship. Its mean bioavailability was 44% in individuals without CYP2D6 (poor metabolizers) but 16 and 12% in those individuals with two and three active genes of CYP2D6 (fast and ultrafast metabolizers), respectively. Consequently, the mean total clearances of the oral dose were 27, 151, and 253 L/hour in poor, extensive, and ultrarapid metabolizers, respectively. The 44% bioavailability combined with low systemic clearance of trimipramine in poor metabolizers of CYP2D6 substrates results in a very high exposure to trimipramine with the risk of adverse drug reactions. On the other hand, the presystemic elimination may result in subtherapeutic drug concentrations in carriers of CYP2D6 gene duplications with a high risk of poor therapeutic response

Clinical Use

Although trimipramine has the weakest binding affinity for the monoamine transporters, it shares the pharmacological and toxicity actions of the other TCAs and is used primarily in the treatment of depression.

Trimipramin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Trimipramin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 48)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30225 58
Shaanxi Didu New Materials Co. Ltd
+8617792793228
1069@dideu.com China 8561 58
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 19956 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
+8618950047208
ellena@amitychem.com China 43414 58
DAYANG CHEM (HANGZHOU) CO.,LTD
+86-88938639 +86-17705817739
info@dycnchem.com China 53803 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
info@yuhaochemical.com China 6387 52
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871
2819742715@qq.com China 4000 55

739-71-9(Trimipramin)Verwandte Suche:


  • 2’-metil-3’-dimetilamino-propil-5-iminodibenzile
  • 2'-Metil-3'-dimetilamino-propil-5-iminodibenzile
  • 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethyl-1-propanamine
  • 5-(3-(Dimethylamino)-2-methylpropyl)-10,11-dihydro-5H-dibenz(b,f)azepine
  • 5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5h-dibenzo(b,f)azepi
  • 5-(gamma-Dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
  • 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-
  • 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-
  • 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-
  • 7162 RP
  • 7162rp
  • beta-Methylimipramine
  • f)azepine,10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-5h-dibenz(
  • f)azepine,5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-5h-dibenz(
  • TRIMIPRAMINE
  • 1-(3-Dimethylamino-2-methylpropyl)-4,5-dihydro-2,3:6,7-dibenzazepine
  • 10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenz(b,f)azepine
  • f)azepine-5-propanamine,10,11-dihydro-n,n,beta-trimethyl-5h-dibenz(
  • FI 6120
  • IL 6001
  • il6001
  • Rhotrimine
  • RP-7162
  • Sapilent
  • Surmontil
  • Surmontil 315695
  • surmontil315695
  • Trimeprimina
  • Trimeprimine
  • Trimeproprimine
  • TRIMIDRAMINE
  • TRIMIPRAMINE,1.0MG/MLINMETHANOL
  • 5-(g-Dimethylamino-b-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
  • 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro- (6CI, 7CI, 8CI)
  • 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,b-trimethyl- (9CI)
  • b-Methylimipramine
  • Trimipramine (base and/or unspecified salts)
  • Trimipramine solution
  • 5-(3-dimethylamino-2-methylpropyl)-10,11-dihydrodibenz(b,f)azepine
  • Trimipramine Solution, 100ppm
  • 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,β-trimethyl-
  • TRIMIPRAMINE USP/EP/BP
  • 5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N,b-trimethyl-
  • Stangyl
  • 739-71-9
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