MERBARONE

97534-21-9

CAS-Nr.: 97534-21-9

Englisch Name:: MERBARONE

Synonyma:: RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide

CBNumber:: CB4494665

Summenformel:: C11H9N3O3S

Molgewicht:: 263.27

MOL-Datei:: 97534-21-9.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 49

MERBARONE Eigenschaften

Dichte: 1.51±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

L?slichkeit: DMSO: >5mg/mL

Aggregatzustand: solid

pka: -2.16±0.20(Predicted)

Farbe: Pink to purple

InChI: 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)

InChIKey: GFYRZTLCYQQVHZ-UHFFFAOYSA-N

SMILES: Sc1nc(c(c(n1)O)C(=O)Nc2ccccc2)O

Sicherheit

WGK Germany	3
RTECS-Nr.	UV7714625
Speicherklasse	11 - Combustible Solids

MERBARONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Merbarone has been used to study its effect on the occurrence of DNA lesions.

Allgemeine Beschreibung

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 μM for purified mammalian topo II versus IC₅₀ = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

Biochem/physiol Actions

Cell permeable: yes

MERBARONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MERBARONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 49)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9345	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai YuanYe Biotechnology Co., Ltd.	13636370518	shyysw007@163.com	China	89686	60
Chunchuang (Wuhan) Technology Co., Ltd	15727060112	yutianchun2007@126.com	China	9865	58
Shanghai Naiys Biological Technology Co., Ltd	18321139117	316441092@qq.con	China	3062	58
Zhengzhou convergence chemical co., LTD	037155153829 18003835034	3897192574@qq.com	China	9977	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59936	58

5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID
5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
NSC-336628
hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
MERBARONE
4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
Merbarone - CAS 97534-21-9 - Calbiochem
5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-
RLBN1001
RLBN-1001
4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide , Merbarone
4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
97534-21-9
Reagents
Tools for Gene Regulation Research
Gene Regulation and Expression
Cell Biology
Cell Signaling and Neuroscience
BioChemical

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