Naratriptan Hydrochloride
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- CAS-Nr.
- 143388-64-1
- Englisch Name:
- Naratriptan Hydrochloride
- Synonyma:
- Naramig;Amerge.;GR-85548A;Nariptan Hydrochloride;Naratriptan Nitrate USP;GR-85548A hydrochloride;Naratriptan Hydrochloride;Naratryptan hydrochloride;Naratriptan monohydrochloride;Naratriptan HCl (GR-85548A HCl)
- CBNumber:
- CB4500391
- Summenformel:
- C17H25N3O2S.ClH
- Molgewicht:
- 371.93
- MOL-Datei:
- 143388-64-1.mol
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Naratriptan Hydrochloride Eigenschaften
- Schmelzpunkt:
- 234-236°C
- storage temp.
- -20°C Freezer
- L?slichkeit
- H2O: ≥10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Wasserl?slichkeit
- H2O: ≥10mg/mL
- InChI
- 1S/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14;/h3-4,11-12,14,18-19H,5-10H2,1-2H3;1H
- InChIKey
- AWEZYKMQFAUBTD-UHFFFAOYSA-N
- SMILES
- Cl.CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| HS Code |
2935904000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Naratriptan Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Naramig was launched in Germany, Sweden and the UK for use in migraine.
It is chemically available via a number of related synthetic routes all having about
three steps starting from 5-bromoindole. It is a new serotonin 5-HT
1B/1D receptor
antagonist with modest affinity for 5-HT
1a, and very weak affinity for 5-HT
3 receptors. It
has little or no affinity for a wide range of non-serotonin receptors including a- and padrenoceptors,
dopamine, neurokinin NK
1, and opiate receptors. It mediates
vasoconstriction in cerebral vasculature (extra cerebral intracranial vessels), reduces
neurogenic inflammation, and inhibits responses mediated by the trigeminal nerves. It
has a 6- and 3-fold greater affinity for 5-HT
1B, and 5-HT
1D, receptors, respectively, than
sumatriptan which translates to a 2-3 fold increase in potency. The reoccurance of
headache was less compared to sumatriptan, zolmitriptan and rizatriptan. Naramig
had no clinical effects on blood pressure or heart rate, had a long duration of action
with very good tolerability, and has high oral bioavailability.
Chemische Eigenschaften
Beige Solid
Verwenden
Naratriptan Hydrochloride is a triptan drug and is used for the treatment of migraine headaches
Naratriptan Hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Naratriptan Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 186)Lieferanten
143388-64-1()Verwandte Suche:
- NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI)
- Amerge.
- Naramig
- Naratriptan Hydrochloride
- N-Methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide Hydrochloride
- N-Methyl-3-(1-methylpiperidin-4-yl)-1H-indole-5-ethanesulfonamide hydrochloride
- Naratriptan monohydrochloride
- Naratriptan Hydrochloride (125 mg)
- 1H-Indole-5-ethanesulfonaMide,N-Methyl-3-(1-Methyl-4-piperidinyl
- N-Methyl-2-(3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl)ethanesulfonaMide hydrochloride
- Nariptan Hydrochloride
- Naratriptan Nitrate USP
- 1H-Indole-5-ethanesulfonaMide,N-Methyl-3-(1-Methyl-4-piperidinyl)-, hydrochloride (1:1)
- GR-85548A
- N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride
- 1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-,hydrochloride
- NARATRIPTAN HYDROCHLORIDE (125 MG)F0C36099%8MG/MG(AI)
- GR-85548A hydrochloride
- Naratriptan Hydrochloride USP/EP/BP
- Naratryptan hydrochloride
- Naratriptan HCl (GR-85548A HCl)
- Naratriptan HydrochlorideQ: What is
Naratriptan Hydrochloride Q: What is the CAS Number of
Naratriptan Hydrochloride Q: What is the storage condition of
Naratriptan Hydrochloride
- Naratriptan Hydrochloride (1457469)
- N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide hydrochloride
- 2-[3-(1-Methyl- piperidin-4-yl) -1H-indol-5-yl]- ethanesulfonic acid methylamide. Hydrochloride, USP
- Naratriptan hydrochloride, 10 mM in DMSO
- 1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)-, hydrochloride (1:1) (ACI)
- 143388-64-1
- C17H25N3O2SHCl
- C17H25N3O2SClH
- C17H26ClN3O2S
- Amerge, Naramig
- Pharmaceuticals
- Inhibitors
- APIs
- Intermediates & Fine Chemicals
