OLOMOUCINE II

500735-47-7

CAS-Nr.: 500735-47-7

Englisch Name:: OLOMOUCINE II

Synonyma:: Nsc736738;Olomoucine II, CDK/cyclin inhibitor;Olomoucine II - CAS 500735-47-7 - Calbiochem;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-

CBNumber:: CB4504061

Summenformel:: C19H26N6O2

Molgewicht:: 370.45

MOL-Datei:: 500735-47-7.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 24

OLOMOUCINE II Eigenschaften

Siedepunkt:: 618.5±65.0 °C(Predicted)

Dichte: 1.32

storage temp.: −20°C

L?slichkeit: chloroform: 50 mg/mL, soluble

Aggregatzustand: powder

pka: 9.83±0.30(Predicted)

Farbe: colorless

InChI: 1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)

InChIKey: NDUVSANREQEDRE-UHFFFAOYSA-N

Sicherheit

S-S?tze:	22-24/25
WGK Germany	3
Speicherklasse	11 - Combustible Solids

OLOMOUCINE II Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Allgemeine Beschreibung

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC₅₀ of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC₅₀ = 50 nM), Roscovitine (Cat. No. 557360; IC₅₀ = 450 nM), Bohemine (Cat. No. 203600; IC₅₀ = 1.1 μM) and Olomoucine (Cat. No. 495620; IC₅₀ = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC₅₀ = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

OLOMOUCINE II Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

OLOMOUCINE II Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 24)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9751	55
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2983	58
Changzhou Chenhong Biotechnology Co., Ltd.	+86-0519-85788828 +86-13775037613	sales@chemrenpharm.com	China	4058	58
ChemeGen	18818260767	2625930290@qq.com	China	6973	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24957	58

Nsc736738
Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine
2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol
Olomoucine II - CAS 500735-47-7 - Calbiochem
Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-
Olomoucine II, CDK/cyclin inhibitor
500735-47-7

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