PIMARIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Pimaric acid is a resin acid that has been found in
A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
Verwenden
A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.
PIMARIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PIMAROL
(1R)-7β-Ethenyl-1,2,3,4,4a,5,6,7,8,9,10,10aα-dodecahydro-1,4aβ,7-trimethyl-1α-phenanthrenecarboxylic acid methyl ester
