LFM-A13
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- CAS-Nr.
- 62004-35-7
- Englisch Name:
- LFM-A13
- Synonyma:
- LFM-A13;2-Cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide;2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE;2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-buteneamide;2-Butenamide, 2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-;2-Cyano-3-hydroxy-but-2-enoic acid (2,5-dibromo-phenyl)-amide;ALPHA-CYANO-BETA-HYDROXY-BETA-METHYL-N-(2,5-DIBROMOPHENYL)PROPENAMIDE
- CBNumber:
- CB4720603
- Summenformel:
- C11H8Br2N2O2
- Molgewicht:
- 360
- MOL-Datei:
- 62004-35-7.mol
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LFM-A13 Eigenschaften
- storage temp.
- −20°C
- L?slichkeit
- DMSO: 15 mg/mL
- Aggregatzustand
- powder
- Farbe
- white
- InChI
- 1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)
- InChIKey
- UVSVTDVJQAJIFG-UHFFFAOYSA-N
LFM-A13 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
LFM-A13 is a novel anti-leukemic agent targeting Bruton''s tyrosine kinase (BTK). LFM-A13 is a BTK inhibitor.
Biologische Aktivit?t
Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC 50 value of 2.5 μ M and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μ M.
LFM-A13 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LFM-A13 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 110)Lieferanten
- LFM-A13
- 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-buteneamide
- 2-CYANO-N-(2,5-DIBROMOPHENYL)-3-HYDROXY-2-BUTENAMIDE
- ALPHA-CYANO-BETA-HYDROXY-BETA-METHYL-N-(2,5-DIBROMOPHENYL)PROPENAMIDE
- 2-Cyano-3-hydroxy-but-2-enoic acid (2,5-dibromo-phenyl)-amide
- 2-Butenamide, 2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-
- 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide
- 62004-35-7
- C11H8Br2N2O2
- Protein Kinase
- Growth Factors and Cytokines
- Intracellular Signaling
