6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
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- CAS-Nr.
- 52853-40-4
- Englisch Name:
- 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
- Synonyma:
- 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide;2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide;Nsc253943;Methotrexate Impurity 15;Methotrexate Impurity 16;Methotrexate Impurity 17 HBr;6-Bromoethyl-pteridine-2,4-diamine;6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR;2, 4-diaMino-6-(broMoMethyl)-pteridine HCL;6-Bromomethyl-pteridine-2,4-diamine hydrobromide
- CBNumber:
- CB51010881
- Summenformel:
- C7H8Br2N6
- Molgewicht:
- 335.99
- MOL-Datei:
- 52853-40-4.mol
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Eigenschaften
- Schmelzpunkt:
- >195°C (dec.)
- storage temp.
- -20°C Freezer
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Light Brown to Brown
- InChI
- InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
- InChIKey
- KMQIBGKVZDBGAH-UHFFFAOYSA-N
- SMILES
- NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.
Chemische Eigenschaften
Light Brown Solid
Verwenden
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.
Application
6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 170)Lieferanten
52853-40-4()Verwandte Suche:
- 2, 4-diaMino-6-(broMoMethyl)-pteridine HCL
- 2,4-diamino-6-(bromomethyl)pteridine(for methotrexate)
- 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
- 2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
- 2,4-PteridinediaMine, 6-(broMoMethyl)-, MonohydrobroMide
- 6-(BroMoMethyl)-2,4-pteridinediaMine HydrobroMide (Technical Grade)
- Nsc253943
- 6-Bromomethyl-pteridine-2,4-diamine hydrobromide
- 2,4-PteridinediaMine, 6-(broMoMethyl)-, hydrobroMide (1:1)
- 6-(Bromomethyl)-2,4-pteridinediamine hydrochloride
- 6-(Bromomethyl)pteridine-2,4-diamine hydrobromide (1:1)
- Methotrexate Impurity 15
- 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide, tech grade
- Methotrexate Impurity 16
- 6-Bromomethyl-pteridine-2,4-diamine hbrQ: What is
6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the CAS Number of
6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the storage condition of
6-Bromomethyl-pteridine-2,4-diamine hbr Q: What are the applications of
6-Bromomethyl-pteridine-2,4-diamine hbr
- 2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide
- Methotrexate Impurity 17 HBr
- 6-(bromomethyl)-2,4-Pteridinediamine hydrobromide (1:1)
- 6-Bromoethyl-pteridine-2,4-diamine
- 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide
- 52853-40-4
- C7H72N6HBr
- C7H8Br2N6
- BrHC7H7BrN6
- C7H7BrN6BrH
- Aromatics
- Bases & Related Reagents
- Inhibitors
- Nucleotides
- Aromatics Compounds
