Entacapone Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Comtan,Orion Corporation
Manufacturing Process
N,N-Diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide (2-
Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl).
A solution containing 1.83 g of 3,4-dihydroxy-5-nitrobenzaldehyde, 1.5 g of
N,N-diethylcyanoacetamide and catalytic amount of piperidine acetate in 40
ml of dry ethanol was refluxed over night. After cooling the solvent was
evaporated in vacuo and the residue was recrystallized from waterdimethylformamide. Yield of desired product was 2.23 g (73%), melting point
153°-156°C.
Therapeutic Function
Antiparkinsonian
Entacapone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
