Glafenin
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- CAS-Nr.
- 3820-67-5
- Bezeichnung:
- Glafenin
- Englisch Name:
- 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
- Synonyma:
- glafenin;glafenine;r1707;glifan;Alcidon;adalgur;Gilfanar;glifanar;privadol;alicidon
- CBNumber:
- CB5107351
- Summenformel:
- C19H17ClN2O4
- Molgewicht:
- 372.8
- MOL-Datei:
- 3820-67-5.mol
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Glafenin Eigenschaften
- Schmelzpunkt:
- 170℃
- Siedepunkt:
- 618℃
- Dichte
- 1.428
- Brechungsindex
- 1.6800 (estimate)
- Flammpunkt:
- 328℃
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- DMSO:100.0(Max Conc. mg/mL);268.24(Max Conc. mM)
- Aggregatzustand
- Solid
- pka
- pKa (20°C) 7.2
- Farbe
- Light yellow to yellow
- Wasserl?slichkeit
- 38.46g/L(temperature not stated)
Glafenin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Glafenine is a non-narcotic analgesic agent. Glafenine shows significant antiinflammatory activity. Glafenine is widely used for the treatment of pains of various origins.
Definition
ChEBI: A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain
but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Weltgesundheitsorganisation (WHO)
Glafenine, a quinolylanthranilate derivative, was introduced in
1965 for use as an analgesic. By the late 1970s its use had been associated with
severe allergic responses, including anaphylactoid reactions, which led to its
withdrawal in one country whereas in others a warning to this effect is required in
the product information. In 1992, on the advice of the Committee for Proprietary
Medicinal Products of the European Communities, glafenine was eventually
withdrawn worldwide by the major manufacturer.
Hazard
Moderately toxic by ingestion. Human systemic
effects.
Glafenin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Glafenin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 81)Lieferanten
3820-67-5(Glafenin)Verwandte Suche:
- GLAFENINE FREE BASE
- Glafeninum
- 1-glyceryl n-(7-chloro-4-quinolyl)anthranilate
- 2-[(7-Chloroquinolin-4-yl)amino]benzoic acid 2,3-dihydroxypropyl
- Alcidon
- Gilfanar
- 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate
- 2-[(7-chloro-4-quinolyl)amino]benzoic acid glyceryl ester
- 1-[N-(7-Chloro-4-quinolyl)anthranilate]glycerol
- 2,3-Dihydroxypropyl N-(7-chloro-4-quinolyl)anthranilate
- 2-[(7-Chloro-4-quinolinyl)aMino]benzoic Acid 2,3-Dihydroxypropyl Ester
- 2-[(7-Chloro-4-quinolyl)aMino]benzoic Acid α-Glyceride
- 4-[(2-Carboxyphenyl)aMino]-7-chloroquinoline α-Monoglyceride
- 4-[2-(β,γ-Dihydroxypropoxycarbonyl)phenylaMino]-7-chloroquinoline
- N-(7-Chloro-4-quinolyl)anthranilic Acid 2,3-Dihydroxypropyl Ester
- 2,3-Dihydroxypropyl-N-(7-chloro-4-quinolinyl)anthranilate
- glifanar
- glycerylaminophenaquine
- privadol
- r1707
- GLAFENINE HYDROCHLORIDE
- 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
- 4-((2-carboxyphenyl)amino)-7-chloroquinolinealpha-monoglyceride
- 4-(2’-(beta,gamma-dihydroxypropoxycarbonyl)phenylamino)-7-chloroquinoleine
- 4-(2’-beta,gamma-dihydroxypropoxycarbonylphenylamino)-7-chloroquinoline
- adalgur
- alicidon
- anthranilicacid,n-(7-chloro-4-quinolyl)-,2,3-dihydroxypropylester
- benzoicacid,2-((7-chloro-4-quinolinyl)amino)-,2,3-dihydroxypropylester
- dolomate
- glaphenin
- glaphenine
- glicafan
- glifan
- glifanan
- Glafenine,inhibit,Inhibitor
- Glafenine, 10 mM in DMSO
- glafenine
- glafenin
- 3820-67-5
- Analytical Standards
- Alphabetic
- Analytical Chromatography Product Catalog
