1,3-dipropyl-8-(3-noradamantyl)xanthine
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- CAS-Nr.
- 136199-02-5
- Englisch Name:
- 1,3-dipropyl-8-(3-noradamantyl)xanthine
- Synonyma:
- MK-7418;KW-3902;HMR-4902;Rolofylline;KW-3902 >=98% (HPLC);Rolofylline, 10 mM in DMSO;KW-3902|||MK-7418|||KF-15372;1,3-dipropyl-8-(3-noradamantyl)xanthine;8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione;8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
- CBNumber:
- CB51337919
- Summenformel:
- C20H28N4O2
- Molgewicht:
- 356.46
- MOL-Datei:
- 136199-02-5.mol
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1,3-dipropyl-8-(3-noradamantyl)xanthine Eigenschaften
- Siedepunkt:
- 578.0±42.0 °C(Predicted)
- Dichte
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble20mg/mL
- Aggregatzustand
- solid
- pka
- 9.23±0.70(Predicted)
- Farbe
- White to off-white
- InChI
- 1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-
- InChIKey
- PJBFVWGQFLYWCB-OYEQCZOJSA-N
- SMILES
- CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)[C@]34C[C@H]5C[C@H](C[C@@H]3C5)C4
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Aquatic Chronic 4 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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1,3-dipropyl-8-(3-noradamantyl)xanthine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
KW 3902 is an antagonist of the adenosine A
1 receptor (K
i = 0.19 nM). It displays 890-fold selectivity for A
1 receptors over A
2A receptors and has no activity at A
3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1; K
i = 7.82 μM). KW 3902 exhibits renal protective effects during hypoxemia in rabbits.
Verwenden
KW 3902 is an adenosine A1-receptor antagonist, which has recently been shown to alleviate axonopathy caused by human Tau ΔK280. KW 3902 can be considered for the development of a treatment towards hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
1,3-dipropyl-8-(3-noradamantyl)xanthine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1,3-dipropyl-8-(3-noradamantyl)xanthine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 51)Lieferanten
- 1,3-dipropyl-8-(3-noradamantyl)xanthine
- HMR-4902
- KW-3902
- Rolofylline
- 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
- MK-7418
- 8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
- 1H-Purine-2,6-dione, 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-
- KW-3902 >=98% (HPLC)
- KW-3902|||MK-7418|||KF-15372
- Rolofylline, 10 mM in DMSO
- 136199-02-5
