ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
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- CAS-Nr.
- 4450-98-0
- Englisch Name:
- ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
- Synonyma:
- 1-Ebpc;CP-10668;Nsc 229530;EBPC, 10 mM in DMSO;EBPC, Aldose reductase inhibitor;Aldose Reductase,inhibit,EBPC,Inhibitor;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
- CBNumber:
- CB51373216
- Summenformel:
- C14H15NO4
- Molgewicht:
- 261.27
- MOL-Datei:
- 4450-98-0.mol
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ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Eigenschaften
- Schmelzpunkt:
- 135-136 °C
- Siedepunkt:
- 479.8±45.0 °C(Predicted)
- Dichte
- 1.340±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- white powder
- pka
- 4.50±1.00(Predicted)
- Farbe
- white
- InChI
- 1S/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,16H,2,8-9H2,1H3
- InChIKey
- IGYRPDIWSYGHMY-UHFFFAOYSA-N
- SMILES
- CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF
2α synthase in response to interleukin-
1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC
50 value of 47 nM
in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F
2α (PGF
2α) and PGE
2 production in human endometrial cells with an EC
50 value of 10 μM.
Verwenden
A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 32)Lieferanten
4450-98-0()Verwandte Suche:
- 1-Ebpc
- 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
- Nsc 229530
- 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
- 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester
- 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester
- CP-10668
- Aldose Reductase,inhibit,EBPC,Inhibitor
- EBPC, Aldose reductase inhibitor
- EBPC, 10 mM in DMSO
- 4450-98-0
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pfizer Compounds
- Pharmaceuticals
