Pegvisomant Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Treatment
of acromegaly (competitive inhibition of peripheral growth
hormone receptors to block IFG-I production).
Biologische Funktion
This product contains 191 amino acid residues (of recombinant origin), the same number as in
GH, but there are substitutions at residues 18, 21, 120, 167, 168, 171, 172, 174, and 179. This
product is then covalently linked to several polyethylene glycol molecules, and this pegylated
protein is a GH-receptor antagonist. Thus, pegvisomant binds to the GH receptor and blocks
endogenous GH from binding. The result is a blocking of the GH-stimulated overproduction of
IGF-I that contributes to the disabling symptoms and long-term health problems associated with
acromegaly.
Pegvisomant Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
