RU 58841
|
|
|
- CAS-Nr.
- 154992-24-2
- Englisch Name:
- RU 58841
- Synonyma:
- PSK-3841;HMR-3841;4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile;CS-637;RU 5884;RU 58841;RU 588841;54RU 58841;Ru58841
CAS;RU 58841(RU-58841)
- CBNumber:
- CB51396657
- Summenformel:
- C17H18F3N3O3
- Molgewicht:
- 369.34
- MOL-Datei:
- 154992-24-2.mol
|
RU 58841 Eigenschaften
- Siedepunkt:
- 493.6±55.0 °C(Predicted)
- Dichte
- 1.39
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
- Aggregatzustand
- Powder
- pka
- 15.09±0.10(Predicted)
- Farbe
- White to off-white
- InChI
- InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
- InChIKey
- ARBYGDBJECGMGA-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(N2C(=O)N(CCCCO)C(C)(C)C2=O)C=C1C(F)(F)F
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H290 |
Kann gegenüber Metallen korrosiv sein. |
Korrosiv gegenüber Metallen |
Kategorie 1 |
Warnung |
|
P234, P390, P404 |
| H314 |
Verursacht schwere Ver?tzungen der Haut und schwere Augensch?den. |
?tzwirkung auf die Haut |
Kategorie 1B |
Achtung |
|
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
|
| Sicherheit |
| P234 |
Nur im Originalbeh?lter aufbewahren. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P330+P331 |
BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P390 |
Verschüttete Mengen aufnehmen, um Materialsch?den zu vermeiden. |
| P406 |
In korrosionsbest?ndigem/… Beh?lter mit korrosionsbest?ndiger Auskleidung aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
RU 58841 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.
Verwenden
RU 58841, is a specific androgen receptor antagonist or anti-androgen, that has shown to have effect on hair growth.
synthetische
RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography.
Alternative synthesis of the anti-baldness compound RU58841
Synthesis Reference(s)
A bromine–nitro substitution at tertiary carbon and using 2-nitropropane as leaving group enable a short phosgene-free synthesis of RU58841.
pubs.rsc.org
Biologische Aktivit?t
Androgens are mainly produced in the adrenal glands and testes. They are male hormones responsible for sex-related development. The well-known androgen is testosterone. Dihydrotestosterone (DHT) is also an androgen, which is a byproduct of testosterone. Although DHT is important for male development and physical health, it can cause hair loss. RU58841 is a topical anti-androgen drug that counteracts the effects of dihydrotestosterone (DHT) by binding to the androgen receptors of the hair follicles, preventing DHT from interacting with the androgen receptors of the hair follicles. Therefore, the hair shrinkage process does not begin, ensuring that the hair undergoes a normal growth cycle.
RU 58841 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
RU 58841 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 282)Lieferanten
154992-24-2()Verwandte Suche:
- RU 58841
- 4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile
- 4-[3-(4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl)benzonitrile
- Benzonitrile, 4-[3-(4-hydroxybutyl)-4,4-diMethyl-2,5-dioxo-1-iMidazolidinyl]-2-(trifluoroMethyl)-
- RU 58841(RU-58841)
- 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile RU 58841
- RU 5884
- 4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile(RU 58841)
- RU-58841 E:candyli(at)speedgainpharma(dot)com
- CS-637
- RU 588841
- RU58841;RU 58841;RU-58841
- Benzonitrile,4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(triflu
- 4-[3-(4-hydroxy-butyl)-4, 4-dimethyl-2, 5-dioxy-1-imidazolyl]-2-(trifluoromethyl) benzonitrile
- 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-y...
- HMR-3841
- API Setipiprant/RU58841 Powder Dosage Usage Effect and Benefit
- 54RU 58841
- Ru58841
CAS
- RU 58841, 10 mM in DMSO
- RU58841 (PSK-3841 or HMR-3841)
- 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazoleoline]-2-(trifluorinemethyl)benzonitrile
- RU 58841 (Standard)
- 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
- PSK-3841
- 154992-24-2
- 862189-61-6
- Inhibitors
- 154992-24-2
