ANTI-CALPAIN-13 (DOMAIN III, N-TERMINAL), LARGE SUBUNIT Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Anti-Calpain-13 is suitable for immunohistochemistry, immunoprecipitation and indirect ELISA. It is also suitable for western blot at a dilution of 1:1,000
Allgemeine Beschreibung
Calpains are calcium-activated, non-lysosomal cysteine proteases that cleave cytoskeletal and submembranous proteins. It is an intracellular cysteine protease that is present in all mammalian tissues. Anti-Calpain-13 (Domain I, N-Terminal), Large Subunit is developed in rabbit using a synthetic peptide corresponding to domain I of the large subunit of human calpain 13 (capn-13) as immunogen. The antibody is affinity purified using agarose to which the immunogen peptide has been bound.
Biochem/physiol Actions
Calpains are involved in a variety of processes including cytoskeletal reorganization, muscle protein degradation, cell proliferation, differentiation, and vesicular secretion. Anti-Calpain-13 (Domain I, N-Terminal), Large Subunit recognizes domain I in the large subunit of human calpain 13 by various immunochemical techniques including immunoblotting, immunoprecipitation, immunohistochemistry, and ELISA. It detects human, rat, and mouse calpain 13 and does not crossreact with other calpain family members (calpain 1, calpain 2, calpain 3, etc.). The antibody binds to the reduced and non-reduced protein. By immunoblotting against the reduced protein, the antibody identifies bands at approximately 64 kDa, 52 kDa, 48 kDa, 40 kDa, and aseries of smaller forms.
ANTI-CALPAIN-13 (DOMAIN III, N-TERMINAL), LARGE SUBUNIT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
