Merck SIP Agonist Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P₁; IC₅₀ = 0.6 nM). It selectively binds S1P₁ over S1P₂, S1P₃, and S1P₄ receptors (IC₅₀s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P₅ receptors (IC₅₀ = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ).

Merck SIP Agonist Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Merck SIP Agonist Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Nanjing Norris-Pharm Technology Co., Ltd	18652989687	sales@norris-pharm.com	China	8878	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2782	58
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Nanjing KaiMubo Pharmaceutical Co., Ltd.	025-66162170		China	7181	55

---

• Merck SIP Agonist
• butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid
• 1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
• 3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
• 1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid
• CS-126
• CAY10734
• SHQNRSGKLNMHOS-UHFFFAOYSA-N
• 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid
• 635701-59-6