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[CAS NO. 486-56-6]??Cotinine

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PRODUCTS SPECIFICATIONS [486-56-6]

Catalog
HY-B1178
Brand
MCE
CAS
486-56-6

DESCRIPTION [486-56-6]

Overview

MDLMFCD00077696
Molecular Weight176.22
Molecular FormulaC10H12N2O
SMILESO=C1N(C)[C@H](C2=CC=CN=C2)CC1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke [1]


IC50 & Target

Human Endogenous Metabolite


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00217893 San Diego State University|National Heart, Lung, and Blood Institute (NHLBI)
Lung Diseases|Asthma
February 2003 Not Applicable
NCT00879918 University of California, San Francisco
Cigarette Smoking
December 2008 Phase 1
NCT02897401 Assistance Publique - H?pitaux de Paris
Smoking|Carcinogenesis of the Nicotine
September 2016 Not Applicable

Appearance

<40°C Solid,>42°C Liquid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

Ethanol : 120 mg/mL ( 680.97 mM ; Need ultrasonic)

DMSO : 65 mg/mL ( 368.86 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6747 mL 28.3736 mL 56.7472 mL
5 mM 1.1349 mL 5.6747 mL 11.3494 mL
10 mM 0.5675 mL 2.8374 mL 5.6747 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.17 mg/mL (12.31 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (12.31 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.17 mg/mL (12.31 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-
Cotinine
2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)-
(5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
(-)-Cotinine
S-(-)-Cotinine
(S)-Cotinine
NIH 10498
(5S)-1-Methyl-5-pyridin-3-ylpyrrolidin-2-one

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