2-Hydrazinoethanol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Clear colorless oily liquid
Verwenden
2-Hydroxyethylhydrazine is used as an intermediate, plant growth regulator, flowering inducer for pineapples.
synthetische
2-Hydroxyethylhydrazine is prepared by heating about 2 to 17 parts of hydrazine hydrate dissolved in water to about 30℃ to about 100℃. in a closed system. Then, 1 part of ethylene oxide is gradually added to the hydrazine hydrate, and the temperature of the reaction mixture is maintained in the range of about 30℃ to 70℃ during the addition.
Allgemeine Beschreibung
2-Hydroxyethylhydrazine reacts with β-diketones having strong electron-withdrawing substituents to yield 5-hydroxy-4,5-dihydropyrazoles.
Hazard
Moderate fire risk. Irritant.
Biologische Aktivit?t
2-Hydroxyethylhydrazine (HEH) is a potent and highly specific inhibitor of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae. Following HEH addition to culture medium, the incorporation of L-[3-
14C]serine, L-[methyl-
14C]methionine, and S-adenosyl-L-[methyl-
14C]methionine into phosphatidylcholine was markedly reduced. In the presence of this inhibitor, cells ceased growth with an IC50 value of 66 pM. Although cellular activity remained unaffected, the addition of choline restored cell growth. This indicates that active phospholipid methylation is unnecessary as long as phosphatidylcholine is supplied via the CDP-choline pathway. The restoration of cell growth by choline suggests that HEH's primary target in vivo is phospholipid methylation.
2-Hydrazinoethanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
