1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
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- CAS-Nr.
- 722456-31-7
- Englisch Name:
- 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
- Synonyma:
- VAS2870;VAS-2870;VAS 2870;VAS2870 VAS-2870;VAS2870, 10 mM in DMSO;VAS 2870;VAS-2870;VAS2870;NOX Inhibitor III, VAS2870;VAS 2870, NADPH oxidase inhibitor;NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem;2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
- CBNumber:
- CB51977298
- Summenformel:
- C18H12N6OS
- Molgewicht:
- 360.39
- MOL-Datei:
- 722456-31-7.mol
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1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Eigenschaften
- Siedepunkt:
- 627.0±65.0 °C(Predicted)
- Dichte
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: ≥5mg/mL
- Aggregatzustand
- Tan solid
- pka
- 0.85±0.30(Predicted)
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
- InChIKey
- HZSOKHVVANONPV-UHFFFAOYSA-N
- SMILES
- C1=NC(SC2=NC3=CC=CC=C3O2)=C2N=NN(CC3=CC=CC=C3)C2=N1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
VAS 2870, is a NADPH oxidase (NOX) inhibitor.
Allgemeine Beschreibung
A cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC
50 = 10.6 μM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 μM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 μM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 μM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 μM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats
ex vivo (by 41.7 and 34.5%, respectively, at 10 μM).
Biochem/physiol Actions
VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 111)Lieferanten
722456-31-7()Verwandte Suche:
- 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
- 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine
- 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
- VAS 2870
- VAS-2870
- NOX Inhibitor III, VAS2870
- 2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
- NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem
- VAS 2870;VAS-2870;VAS2870
- 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-(2-benzoxazolylthio)-3-(phenylmethyl)-
- VAS2870 VAS-2870
- VAS 2870, NADPH oxidase inhibitor
- VAS2870, 10 mM in DMSO
- VAS2870
- 722456-31-7
- 722546-31-7
- C18H12N6OS
