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Ethyl 4-methoxycinnamate

Ethyl 4-methoxycinnamate Struktur
24393-56-4
CAS-Nr.
24393-56-4
Englisch Name:
Ethyl 4-methoxycinnamate
Synonyma:
ETHYL P-METHOXYCINNAMATE;Ethyl trans-4-methoxycinnamate;4-METHOXYCINNAMIC ACID ETHYL ESTER;ETHYL 3-(4-METHOXYPHENYL)ACRYLATE;ethyl (E)-4-methoxycinnamate;(E)-Ethyl p-methoxycinnamate;EPMC;RARECHEM AL BI 0241;Ethyl 4-Methoxyciamate;Ethyl 4-methoxycinmate
CBNumber:
CB5205790
Summenformel:
C12H14O3
Molgewicht:
206.24
MOL-Datei:
24393-56-4.mol

Ethyl 4-methoxycinnamate Eigenschaften

Schmelzpunkt:
49°C
Siedepunkt:
187 °C / 15mmHg
Dichte
1.080±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
Off-White
Wasserl?slichkeit
insoluble in water
BRN 
2210033
Major Application
food and beverages
InChI
InChI=1S/C12H14O3/c1-3-15-12(13)9-6-10-4-7-11(14-2)8-5-10/h4-9H,3H2,1-2H3/b9-6+
InChIKey
DHNGCHLFKUPGPX-RMKNXTFCSA-N
SMILES
C(OCC)(=O)/C=C/C1=CC=C(OC)C=C1
LogP
2.650 (est)
NIST chemische Informationen
Ethyl p-methoxycinnamate(24393-56-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
R-S?tze: 36/37/38
S-S?tze: 26-36/37/39-24/25
WGK Germany  3
HS Code  29189900
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Ethyl 4-methoxycinnamate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White crystalline, soluble in methanol, ethanol, DMSO and other organic solvents, derived from cinnamon.

Verwenden

Ethyl 4-methoxycinnamate is an derivative of 4-methoxycinnamic acid, an antihyperglycemic/hypoglycemic agent that works by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.

synthetische

Ethyl 4-methoxycinnamate synthesis: 4-Methoxycinnamic Acid (0.60 g, 3.36 mmol) was dissolved in 10 mL of dry N,N-dimethylformamide (DMF) in a 25-mL, roundbottomed flask. Cesium carbonate (1.65 g, 5.06 mmol) was added followed by iodoethane (1.0 mL, 12.5 mmol). The flask was capped (rubber septum) and the heterogeneous mixture stirred vigorously at 50 °C for one hour. After this time, HCl (1.0 M, 4.0 mL) was added to quench the reaction. The liquid was decanted from any remaining solid and extracted with 3 : 1 hexanes/ethyl acetate (2 x 10 mL). The organic layer was washed with brine (20 mL), dried with MgSO4, filtered, and solvent removed. The remaining oil solidified on standing to form colorless prisms.
Synthesis of ethyl 4-methoxycinnamate
Synthesis of ethyl 4-methoxycinnamate

Allgemeine Beschreibung

Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats. It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (<10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.

Ethyl 4-methoxycinnamate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ethyl 4-methoxycinnamate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 279)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+86-28-82633860; +8618080483897
sales@biopurify.com China 3751 58
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58
SIMAGCHEM CORP
+86-5922680277 +86-13806087780
sale@simagchem.com China 17346 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10236 58

24393-56-4()Verwandte Suche:


  • 3-(4-METHOXYPHENYL)ACRYLIC ACID ETHYL ESTER
  • ETHYL 4-METHOXYCINNAMATE
  • RARECHEM AL BI 0241
  • Methoxycinnamicacidethylester
  • 4-METHOXYCINNAMIC ACID ETHYL ESTER 98+%
  • P-methoxyl ethyl cinnamate
  • 4-Methoxycinnamic Acid Ethyl Ester Ethyl 3-(4-Methoxyphenyl)acrylate 3-(4-Methoxyphenyl)acrylic Acid Ethyl Ester
  • ParaMethoxyethylcinnaMate
  • 1-(tert-butoxycarbonyl)-4-(4-Methoxyphenyl)pyrrolidine-3-carboxylic acid
  • (E)-Ethyl 3-(4-Methoxyphenyl)acrylate
  • Ethyl 4-Methoxyciamate
  • (E)-3-(4-Methoxyphenyl)-2-propenoic acid ethyl ester
  • Ethyl (E)-3-(4-methoxyphenyl)-2-propenoate
  • trans-4-Methoxycinnamic acid ethyl ester
  • Ethyl 4-methoxycinmate
  • Ethyl para-methoxycinnamate
  • 2-Propenoic acid, 3-(4-methoxyphenyl)-, ethyl ester, (2E)-
  • Ethyl 4-methoxycinnamate USP/EP/BP
  • Ferulic acid,ethyl ester,4-Methoxycinnamic Acid Ethyl Ester,Ethyl trans-4-methoxycinnamate,ethyl p-methoxycinnamate,3-(4-Methoxyphenyl)acrylic Acid
  • Ethyl trans-p-methoxycinnamate
  • trans-p-Methoxycinnamic acid ethyl ester
  • Ethyl4-Methoxycinnamate>
  • EPMC
  • 4-METHOXYCINNAMIC ACID ETHYL ESTER
  • ETHYL P-METHOXYCINNAMATE
  • ethyl (E)-4-methoxycinnamate
  • (E)-Ethyl p-methoxycinnamate
  • Ethyl trans-4-methoxycinnamate-d3
  • trans-p-Methoxycinnamic acid ethyl ester-RM
  • trans-p-Methoxycinnamic acid ethyl ester
  • Cinnamyl Chloride Impurity 38 (Ethyl trans-p-methoxycinnamate)
  • (E)-Ethyl p-methoxycinnamate (Standard)
  • ETHYL 3-(4-METHOXYPHENYL)ACRYLATE
  • Ethyl trans-4-methoxycinnamate
  • 24393-56-4
  • Cinnamic acid
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