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MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1)

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Struktur
CAS-Nr.
Englisch Name:
MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1)
Synonyma:
MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1);Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse
CBNumber:
CB5208140
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Eigenschaften

storage temp. 
−20°C
Aggregatzustand
buffered aqueous solution
Biologische Quelle
mouse

Sicherheit

WGK Germany  3
Speicherklasse 10 - Combustible liquids

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry
  • immunofluorescence staining

Allgemeine Beschreibung

Monoclonal Anti- hPlk1 (Polo Like Kinase 1) (mouse IgG2b isotype) is derived from the 35-206 hybridoma produced by the fusion of mouse myeloma cells (PAI) and splenocytes from BALB/c mice immunized with human full length Plk1. Polo-like kinases (Plks) are a family of serine/threonine kinases. The Plk family is structurally and functionally related to the polo gene in Drosophila. Plk1 localizes during mitosis in centrosomes, kinetochores and in the central spindle.

Biochem/physiol Actions

Polo Like Kinase 1 (Plk1) has a role in tumor progression. Plk1 is a target of the DNA damage checkpoint on the basis that its activity is inhibited by DNA damage in G2 and mitosis. Moreover, Plk1 was found to bind to the sequence-specific DNA binding domain of p53. This interaction between p53 and Plk1 inhibits the transcriptional activation and the proapoptotic functions of p53.

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 3)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Merck KGaA --
ordercn@merckgroup.com China 6394 58

  • Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse
  • MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1)
  • P1 to PNAntibodies for Kinase/Phosphatase Biology
  • Polo-Like-Kinase (PLK)Antibodies
  • Serine/Threonine Kinase Antibodies
  • 3
  • Alphabetical Index
  • Antibodies
  • Clone Index
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