Naftifine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent that works by blocking squalene 2,3-epoxidase, resulting in increased cell membrane permeability and cell death. It is structurally and pharmacologically related to terbinafine. It also has some antiinflammatory properties that may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is most effective against dermatophytes, moderately active against molds, and less active against yeasts, including C. albicans.
Indications
Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent
that works by blocking squalene 2,3-epoxidase, resulting in increased cell
membrane permeability and cell death. It is structurally and pharmacologically
related to terbinafine. It also has some antiinflammatory properties that
may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is
most effective against dermatophytes, moderately active against molds, and
less active against yeasts, including C. albicans.
Definition
ChEBI: A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.
Antimicrobial activity
Naftifine is fungicidal against dermatophytes such as Epidermophyton floccosum, Trichophyton and Microsporum species. Against pathogenic yeasts such as Candida species and moulds, it shows only an intermediate fungistatic activity in vitro.
Pharmazeutische Anwendungen
A topical antifungal used as a 1% cream for the treatment
of dermatophytoses, including tinea pedis, tinea corporis and
tinea cruris.
Clinical Use
Naftifine was the first allyl amine to be discovered and marketed. It is subject to extensive first-pass metabolism to be orally active and, consequently, is only available in topical preparations. The widest use of naftifine is against various tinea infections of the skin.
Naftifine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
