Medetomidine hydrochloride
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- CAS-Nr.
- 86347-15-1
- Englisch Name:
- Medetomidine hydrochloride
- Synonyma:
- MEDETOMIDINE HYDROCHLORIDE;(r)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole hydrochloride;edetomidine;(R)-4-[1-(2;medeomidine hcl;Medetomidine HC;Metetomidine HCl;Medetomidine HCI;Medetomidine HCl Powder;Ethyl Acetate Impurity 85
- CBNumber:
- CB52130917
- Summenformel:
- C13H17ClN2
- Molgewicht:
- 236.74
- MOL-Datei:
- 86347-15-1.mol
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Medetomidine hydrochloride Eigenschaften
- Schmelzpunkt:
- 164-166°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Acetonitrile (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Biologische Quelle
- synthetic
- InChI
- InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
- InChIKey
- VPNGEIHDPSLNMU-UHFFFAOYSA-N
- SMILES
- C(C1N=CNC=1)(C1C=CC=C(C)C=1C)C.Cl
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
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| Hazard Classifications |
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Acute 1
Aquatic Chronic 1
STOT RE 1
STOT SE 1
STOT SE 3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Medetomidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). It is an imidazole compound. Medetomidine hydrochloride shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). In addition, it influences the adrenergic system by mimicking the action of adrenergic neurotransmitters.
Chemische Eigenschaften
White Solid
Indications
Medetomidine hydrochloride is an FDA-approved alpha2-adrenoceptor (α2-AR) agonist with analgesic, sedative and anxiolytic properties for use as a veterinary sedative. It has been approved for use in animals such as cats, sheep, and dogs (12 weeks of age and older.) In 1999, the FDA approved Medetomidine for human use in the sedation of intubated and mechanically ventilated intensive care unit (ICU) patients, including use as a pain reliever and for use in non-intubated patients prior to and during surgery and other procedures. In addition to its pharmaceutical uses, it is used as an antifouling agent in marine coatings.
[1]
Pharmakokinetik
After intramuscular injection, medetomidine is rapidly and almost completely absorbed at the site of injection and its pharmacokinetics are very similar to that observed after intravenous injection. Maximum plasma concentrations are reached within 15 to 20 minutes. Estimated plasma half-life is 1.2 hours for dogs and 1.5 hours for cats. Medetomidine is mainly oxidised in the liver, while a small amount is methylated in the kidney. Metabolites are primarily excreted in urine.
Synthese
Medetomidine hydrochloride is synthesized using 2,3-Dimethylbromobenzene as the starting material through a series of Grignard reactions. This process yields tertiary alcohol 7, which is subsequently subjected to dehydration and hydrogenation. The overall yield achieved was 17 percent.
[1] The reaction scheme is illustrated as follows:
Additional synthetic processes encompass:
Medetomidine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Medetomidine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 252)Lieferanten
86347-15-1()Verwandte Suche:
- 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
- 5-[1-(2,3-diMethylphenyl)ethyl]-1H-IMidazole hydrochloride
- edetomidine
- Medetomidine hydrochloride
(R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
- 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride
- Metetomidine HCl
- (R)-4-[1-(2
- 3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
- Medetomidine (hydrochloride) cas86347-15-1
- SIMS1031 Medetomidine HCl ---86347-15-1
25g
- 2-amino-5-(2-ethoxyanilino)-4-hydroxy-1H-pyrimidin-6-one
- Medetomidine Hcl Medetomidine Hydrochloride
- (R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride USP/EP/BP
- Medetomidine Hydrochloride Impurities
- Metoclopramide (metoclopramide)
- medeomidine hcl
- Medetomidine HCl (MPV-785)
- MEDETOMIDINE HYDROCHLORIDE
- Medetomidine hydrochloride,anxiolysis,inhibit,sedation,Medetomidine,α2-adrenoceptor,MPV-785,peripheral nervous system,analgesia,MPV 785,central nervous system,Inhibitor,muscle relaxation,Beta Receptor,Adrenergic Receptor
- Medetomidine HCl Powder
- Ethyl Acetate Impurity 85
- Medetomidine hydrochloride, alpha2 adrenoceptor agonist (aqueous solution)
- Medetomidine hydrochloride, alpha2 adrenoceptor agonist
- Medetomidine hydrochloride, 10 mM in DMSO
- Medetomidine HCI
- Medetomidine HC
- (r)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole hydrochloride
- 86347-15-1
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
