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Sodium 4-phenylbutyrate

Sodium 4-phenylbutyrate Struktur
1716-12-7
CAS-Nr.
1716-12-7
Englisch Name:
Sodium 4-phenylbutyrate
Synonyma:
SODIUM PHENYLBUTYRATE;PBNA;4PBA;Tributyrate;4-PHENYLBUTYRATE;Ammonaps;Nsc657802;4PBA SODIUM;4-PHENYLBUTYRATE, NA;Sodium 4-Phenylbutyr
CBNumber:
CB5213148
Summenformel:
C10H13NaO2
Molgewicht:
188.2
MOL-Datei:
1716-12-7.mol

Sodium 4-phenylbutyrate Eigenschaften

Schmelzpunkt:
224-226°C (dec.)
storage temp. 
room temp
L?slichkeit
H2O: ≥5mg/mL
Aggregatzustand
White to slightly yellow solid
Farbe
white to beige
Wasserl?slichkeit
water: 10mg/mL
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C10H12O2.Na.H/c11-10(12)8-4-7-9-5-2-1-3-6-9;;/h1-3,5-6H,4,7-8H2,(H,11,12);;
InChIKey
OBKXEAXTFZPCHS-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1)CCC(=O)O.[NaH]
CAS Datenbank
1716-12-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36
S-S?tze: 26
WGK Germany  3
RTECS-Nr. CY9057220
HS Code  29163990
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Sodium 4-phenylbutyrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.
Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Chemische Eigenschaften

White or yellowish-white powder.

Verwenden

ACE inhibitor, antihypertensive, Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.

Definition

ChEBI: The organic sodium salt of 4-phenylbutyric acid. A prodrug for phenylacetate, it is used to treat urea cycle disorders.

Allgemeine Beschreibung

An antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.

Biologische Aktivit?t

Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.

Nebenwirkungen

Loss of appetite or menstrual changes (delayed/irregular/absent periods) may occur. Serious side effects including: drowsiness/lightheadedness, easy bruising/bleeding, fast/pounding heartbeat, mental/mood changes, tiredness, signs of metabolic imbalance (such as rapid breathing, muscle twitching/spasms).

Sodium 4-phenylbutyrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sodium 4-phenylbutyrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 338)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou uniringchem Co., Ltd.
+undefined13585446801
sales@uniringchem.com China 69 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 +86-18829239519
sales06@tgybio.com China 898 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-2158073036
info@dakenam.com China 13901 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88298848
info@edengenechem.com China 2165 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
Jinan Liheng Biotechnology Co., Ltd.
15865262812
info@lihengpharm.com CHINA 938 58

1716-12-7()Verwandte Suche:


  • SODIUM 4-PHENYLBUTYRATE
  • PHENYL N-BUTYRATE SODIUM SALT
  • 4-PHENYLBUTYRATE, NA
  • 4-PHENYLBUTYRIC ACID SODIUM
  • 4-PHENYLBUTYRIC ACID SODIUM SALT
  • 4PBA SODIUM
  • Nsc657802
  • SodiuM 4-Phenylbutanoate
  • Benzenebutanoic acid,sodiuM salt (1:1)
  • Sodium Phenylbutyrate (200 mg)
  • Sodium phenylbutyrate, >=98%
  • Sodium phenylbutyrate, 98%, a histone deacetylase inhibitor
  • Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem
  • Benzenebutyric acid sodium
  • Sodium phenylbutyrate CRS
  • Sodium 4-phenylbutyrate USP/EP/BP
  • Sodium 4-Phenylbutyr
  • Ammonaps
  • Sodium Phenylbutyrate (4-PBA sodium)
  • Sodium Phenylbutyrate (1614512)
  • PBNA
  • 4PBA
  • Tributyrate
  • 4-Phenylbutyric acid sodium in Acetonitrile:Water=9:1
  • Sodium 4-phenylbutyrate, Histone deacetylase inhibitor
  • Sodium 4-phenylbutyrate, 10 mM in DMSO
  • SODIUM PHENYLBUTYRATE USP
  • 4-PBA (Sodium Phenylbutyrate)
  • Sodium 4-phenylbutyrate (4-PBA)
  • 4-PHENYLBUTYRATE
  • SODIUM PHENYLBUTYRATE
  • 1716-12-7
  • 716-12-7
  • C10H11O2Na
  • C10H11NaO2
  • VASOTEC
  • 1716-12-7
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