Nelfinavir mesylate
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- CAS-Nr.
- 159989-65-8
- Englisch Name:
- Nelfinavir mesylate
- Synonyma:
- viracept;Nelfin;AG-1343;Nelfinavir1;Nelfinavir-d9;AG1343 Mesylate;AG-1343 Mesylate;AG 1343 Mesylate;Nelfinavir nesylate;NELFINAVIR MESYLATE
- CBNumber:
- CB5213805
- Summenformel:
- C33H49N3O7S2
- Molgewicht:
- 663.89
- MOL-Datei:
- 159989-65-8.mol
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Nelfinavir mesylate Eigenschaften
- Schmelzpunkt:
- 131-135°C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- DMSO: ≥2mg/mL
- pka
- pKa -1.20(at 25℃)
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Wasserl?slichkeit
- 4.5g/L(temperature not stated)
- Merck
- 14,6443
- BCS Class
- 2,4
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChIKey
- NQHXCOAXSHGTIA-SKXNDZRYSA-N
- SMILES
- CC1=C(O)C=CC=C1C(N[C@@H](CSC2=CC=CC=C2)[C@H](O)CN3[C@H](C(NC(C)(C)C)=O)C[C@@]4([H])[C@@](CCCC4)([H])C3)=O.[CH2]S(O)(=O)=O
- CAS Datenbank
- 159989-65-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Nelfinavir mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Viracept was launched in the US as an orally-available, non-peptidic HIV
protease inhibitor. It is prepared in an eight step synthesis beginning with N-
(benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the
processing of gag and gagpol polyproteins that are required for viral maturation. It
was discovered based on an experimentally derived 3D-structure of HIV-1 protease.
Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile
different from other protease inhibitors. Viracept with ziduvudine and larnivudine
generated a 98% mean reduction from baseline in viral load after 24 weeks compared
to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is
available in adult and pediatric formulations.
Chemische Eigenschaften
White Powder
Verwenden
Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.
Definition
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.
Biologische Aktivit?t
Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .
Nelfinavir mesylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nelfinavir mesylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 310)Lieferanten
159989-65-8()Verwandte Suche:
- Nelfinavir mesylate, >=98%
- Nelfinavir methanesulfonate hydrate
- Nelfinavir mesylate hydrate
- N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-(3S,4aS,8aS)-3-isoquinolinecarboxamide, methanesulfonate (1:1)
- (3S,4aS,8aS)-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methyl-benzoyl)amino]-4-phenylsulfanyl-butyl]-N-tert-butyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
- Nelfinavir1
- AG-1343 Mesylate
- AG1343 Mesylate
- AG 1343 Mesylate
- Nelfinavir (Methanesulfonate)
- Nelfin
- Nelfinavir Mesylate (200 mg)
- (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamidemethanesulfonate
- Nelfinavir nesylate
- NELFINAVIRMESYLATE(SUBJECTTOPATENTFREE)
- (3s,4as,8as)-n-(1,1-dimethylethyl)decahydro-2-[(2r,3r)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide mesylate
- AG-1343
- NELFINAVIR MESYLATE
- (3S,4AS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl
- 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1)
- droxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-,(3s-(2(2,s*,3s*),3-alpha,4
- 8a-beta))-a-betmonomethanesulfonate(salt)
- Nelfinavir-d9
- (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
- Nelfinavir Mesylate (AG 1343 Mesylate)
- Nelfinavir mesylate - AG 1343
- AG 1343 MESYLATE;AG1343 MESYLATE;AG-1343 MESYLATE
- (3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide methanesulfonate
- Nelfinavir MesylateQ: What is
Nelfinavir Mesylate Q: What is the CAS Number of
Nelfinavir Mesylate Q: What is the storage condition of
Nelfinavir Mesylate Q: What are the applications of
Nelfinavir Mesylate
- viracept
- Nelfinavir mesylate salt monohydrate
- Glumetinib Impurity 2
- Nelfinavir Mesylate, 10 mM in DMSO
- Nelfinavir mesylate 98%
- (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide mesylate hydrate
- 159989-65-8
- C33H49N3O7S2
- C32H45N3O4S
- C32H45N3O4SCH4O2S2
- C32H45N3O4SCH4O3SxH2O
- Pfizer compounds
- peptides
- Anti-virals
- Inhibitors
- Intermediates & Fine Chemicals
- Non-nucleoside Reverse Transcriptase
- Pharmaceuticals
- Nelfinavir
- Active Pharmaceutical Ingredients
- Anti-viral Compounds
- Coronavirus
