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Bretyliumtosilat

BRETYLIUM TOSYLATE Struktur
61-75-6
CAS-Nr.
61-75-6
Bezeichnung:
Bretyliumtosilat
Englisch Name:
BRETYLIUM TOSYLATE
Synonyma:
ornid;asl-603;darentin;bretylan;bretylol;bretylate;darenthin;esulfonicacid;ulfonicacid(1:1);BretyliuM p-Tolu
CBNumber:
CB5239348
Summenformel:
C18H24BrNO3S
Molgewicht:
414.36
MOL-Datei:
61-75-6.mol

Bretyliumtosilat Eigenschaften

Schmelzpunkt:
97-99°
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
H2O: soluble50mg/mL
Aggregatzustand
Solid
Farbe
white
Major Application
pharmaceutical (small molecule)
InChI
1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
InChIKey
KVWNWTZZBKCOPM-UHFFFAOYSA-M
SMILES
Cc1ccc(cc1)S([O-])(=O)=O.CC[N+](C)(C)Cc2ccccc2Br

Sicherheit

Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22
S-S?tze: 36
WGK Germany  WGK 3
RTECS-Nr. BO9450000
HS Code  2923900100
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Toxizit?t LD50 in mice (mg/kg): 400 orally; 250 i.m. (Goldenthal)

Bretyliumtosilat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White Solid

Verwenden

Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.

Definition

ChEBI: The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibril ation.

Allgemeine Beschreibung

Bretylium tosylate, (o-bromobenzyl)ethyl dimethylammonium p-toluenesulfonate(Bretylol), is an extremely bitter, white, crystalline powder.The chemical is freely soluble in water and alcohol.Bretylium tosylate is an adrenergic neuronal-blockingagent that accumulates selectively in the neurons anddisplaces norepinephrine. Because of this property,bretylium was used initially, under the trade name ofDarenthin, as an antihypertensive agent. It caused posturaldecrease in arterial pressure. This use was discontinuedbecause of the rapid development of tolerance, erratic oralabsorption of the quaternary ammonium compound, andpersistent pain in the parotid gland on prolonged therapy.

Clinical Use

Currently, bretylium is reserved for use in ventriculararrhythmias that are resistant to other therapy. Bretyliumdoes not suppress phase 4 depolarization, a common actionof other antiarrhythmic agents. It prolongs the effectiverefractory period relative to the action potential durationbut does not affect conduction time and is categorized asa class III antiarrhythmic agent. Because bretylium doesnot have properties similar to those of the other antiarrhythmicagents, it has been suggested that its action is aresult of its adrenergic neuronal-blocking properties; theantiarrhythmic properties of the drug, however, are notaffected by administration of reserpine. Bretylium is also alocal anesthetic, but it has not been possible to demonstratesuch an effect on atria of experimental animals, except atvery high concentrations. Therefore, the precise mechanismof the antiarrhythmic action of bretylium remains tobe resolved.

Nebenwirkungen

The major adverse effect associated with bretylium tosylate is hypotension, including orthostatic hypotension, which may be very severe.

Bretyliumtosilat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bretyliumtosilat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 112)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED

sales@conier.com China 49979 58
TargetMol Chemicals Inc.
+1-781-999-5354; +1-00000000000
marketing@targetmol.com United States 32466 58
Career Henan Chemica Co
+86-0371-86658258 +86-13203830695
laboratory@coreychem.com China 30224 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81139210 +86-17392587031
1059@dideu.com China 9996 58
Finetech Industry Limited
+86-27-8746-5837 +86-18627785180
info@finetechnology-ind.com China 9539 58
BOC Sciences
16314854226; +8616314854226
inquiry@bocsci.com United States 19853 58
Dayang Chem (Hangzhou) Co.,Ltd.
+86-0571-88938639 17705817739
info@dycnchem.com China 52704 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39037 58
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490
info@gihichemicals.com China 49895 58

61-75-6(Bretyliumtosilat)Verwandte Suche:


  • (o-bromobenzyl)ethyldimethyl-ammoniup-toluenesulfonate
  • 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium4-methylbenzenesulfonate
  • 2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzen
  • darentin
  • dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate
  • esulfonicacid
  • n-ethyl-n-o-bromobenzyl-n,n-dimethylammoniumtosylate
  • ornid
  • ulfonicacid(1:1)
  • Bretylium Tosylate (200 mg)
  • BretyliuM p-Tolu
  • N-(2-BroMobenzyl)-N,N-diMethylethanaMiniuM 4-Methylbenzenesulfonate
  • BretyliuM Tosylate USP
  • 2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzenes
  • asl-603
  • bretylan
  • bretylate
  • bretyliump-toluenesulfonate
  • Bretyliumtosilate
  • bretylol
  • darenthin
  • [O-BROMOBENZYL]ETHYLDIMETHYL-AMMONIUM P-TOLUENESULFONATE
  • BRETYLIUM TOSYLATE
  • BRETYLIUM TOSYLATE ADRENERGIC NEURON BLO
  • BRETYLIUM TOSYLATE, PHARMA
  • (2-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate
  • Bretyliume tosylate
  • Retylium tosylate
  • (2-bromobenzyl)-ethyl-dimethyl-ammonium
  • (2-bromophenyl)methyl-ethyl-dimethylazanium
  • (2-bromophenyl)methyl-ethyl-dimethyl-azanium
  • 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium
  • Bretylium Tosylate (1076352)
  • BRETYLIUM TOSYLATE USP/EP/BP
  • inhibit,Inhibitor,Bretylium,Bretylium tosylate
  • Bretylium tosylate, 10 mM in DMSO
  • Benzyltrimethylammonium bromide tosylate
  • 61-75-6
  • C18H24BrNO3S
  • C18H24BO3RnS
  • C11H17BrNC7H7O3S
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
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