trans-N-(1E)-1,3-Butadien-1-yl-carbamic Acid 2,2,2-Trichloroethyl Ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
synthetische
The synthesis of trans-1,3-butadienecarbamates utilizes a modified Curtius rearragement. In the synthesis of
2,2,2-trichloroethyl trans-1,3-butadiene-1-carbamate, Malonic Acid and Acrolein were condensed in pyridine to obtain trans-2,4-
pentadienoic acid in 44-51% yield (eq 1). This compound, which may be stored in a freezer for several months, was treated with
Ethyl Chloroformate and the resulting mixed anhydride transformed into the azide derivative. Due to the explosive nature, the azide
was not isolated but immediately added to a refluxing solution of 2,2,2-Trichloroethanol in toluene. Purification by silica gel column
chromatography (hexane-ethyl acetate = 9:1) then afforded the title compound.
Allgemeine Beschreibung
trans-N-(1E)-1,3-Butadien-1-yl-carbamic Acid 2,2,2-Trichloroethyl Ester is a diene which provides regio- and stereoselective control in Diels-Alder reaction.
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trans-N-(1E)-1,3-Butadien-1-yl-carbamic Acid 2,2,2-Trichloroethyl Ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
