2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
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- CAS-Nr.
- 5291-32-7
- Englisch Name:
- 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
- Synonyma:
- APR-246;Eprenetapopt;PRIMA-1MET;APR246;APR 246;PRIMA-1MET(APR-246);Eprenetapopt (APR246;APR-246 (PRIMA-1MET);PRIMA-1MET;PRIMA-1MET, p53 activity;Eprenetapopt, 10 mM in DMSO
- CBNumber:
- CB52518928
- Summenformel:
- C10H17NO3
- Molgewicht:
- 199.25
- MOL-Datei:
- 5291-32-7.mol
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2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Eigenschaften
- Schmelzpunkt:
- 115-116 °C
- Siedepunkt:
- 313.8±17.0 °C(Predicted)
- Dichte
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO (up to 20 mg/ml)
- Aggregatzustand
- powder
- pka
- 13.99±0.10(Predicted)
- Farbe
- white to beige
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- 1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3
- InChIKey
- BGBNULCRKBVAKL-UHFFFAOYSA-N
- SMILES
- N21CCC(CC2)C(=O)C1(COC)CO
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.
Biochem/physiol Actions
PRIMA-1Met, also called APR-246, is converted to methylene quinuclidinone (MQ), a Michael acceptor. It interacts with p53 through the cysteine (Cys) residue. It blocks the thioredoxin reductase (TrxR1) enzyme. It is under clinical investigation and well-studied. PRIMA-1Met effect is tested on breast cancer specific gene expression.
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 138)Lieferanten
- 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
- PRIMA-1MET
- 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
- 1-Azabicyclo[2.2.2]octan-3-one, 2-(hydroxymethyl)-2-(methoxymethyl)-
- 2-(Hydroxymethyl)-2-(methoxymethyl)-3-quinuclidinone
- PRIMA-1MET 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one APR-246
- APR246;APR 246
- PRIMA-1MET(APR-246)
- APR-246 (PRIMA-1MET)
- Eprenetapopt (APR246
- PRIMA-1MET, p53 activity
- Eprenetapopt, 10 mM in DMSO
- Eprenetapopt (APR-246) ，S7724
- APR-246
- Eprenetapopt
- PRIMA-1MET
- 5291-32-7
