Iron Chelator, Dp44mT
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- CAS-Nr.
- 152095-12-0
- Englisch Name:
- Iron Chelator, Dp44mT
- Synonyma:
- de44mt;Dp44mT;CS-2521;Iron Chelator;Iron Chelator, Dp44mT;Dp44mT, 10 mM in DMSO;Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone;2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide;2-(di(pyridin-2-yl)methylene)-N,N-imethylhydrazinecarbothioamide;2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide
- CBNumber:
- CB52524488
- Summenformel:
- C14H15N5S
- Molgewicht:
- 285.37
- MOL-Datei:
- 152095-12-0.mol
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Iron Chelator, Dp44mT Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥5mg/mL
- Aggregatzustand
- powder
- Farbe
- yellow to orange
- Sensitive
- Light Sensitive
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may ne stored at -20°C for 1 month.
- InChI
- 1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)
- InChIKey
- XOBIGRNRXCAMJQ-UHFFFAOYSA-N
- SMILES
- CN(C)C(=S)N\N=C(\c1ccccn1)c2ccccn2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| HazardClass |
6.1 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Iron Chelator, Dp44mT Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand.
Biochem/physiol Actions
Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer.
Iron Chelator, Dp44mT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Iron Chelator, Dp44mT Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 113)Lieferanten
152095-12-0()Verwandte Suche:
- Iron Chelator, Dp44mT
- 2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide
- Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone
- Dp44mT
- de44mt
- CS-2521
- Iron Chelator
- Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-
- 2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide
- 2-(di(pyridin-2-yl)methylene)-N,N-imethylhydrazinecarbothioamide
- Dp44mT, 10 mM in DMSO
- 152095-12-0
