2-Acetylfuro-1,4-naphthoquinone
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- CAS-Nr.
- 83280-65-3
- Englisch Name:
- 2-Acetylfuro-1,4-naphthoquinone
- Synonyma:
- Napabucasin;Remimazolam besylate;139057;CS-945;BBI-606;Napabucasin Impurity;Napabucasin (BBI608);Napabucasin, 10 mM in DMSO;Napabucasin (BBI608) ，S7977;2-Acetylfuro-1,4-phthoquinone
- CBNumber:
- CB52667637
- Summenformel:
- C14H8O4
- Molgewicht:
- 240.21
- MOL-Datei:
- 83280-65-3.mol
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2-Acetylfuro-1,4-naphthoquinone Eigenschaften
- Schmelzpunkt:
- 225-226℃ (dichloromethane )
- Siedepunkt:
- 444.4±45.0 °C(Predicted)
- Dichte
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- L?slichkeit
- Soluble in DMSO (up to 20 mg/ml)
- Aggregatzustand
- Brown solid
- Farbe
- Yellow
- maximale Wellenl?nge (λmax)
- 272nm(EtOH)(lit.)
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
- InChIKey
- DPHUWDIXHNQOSY-UHFFFAOYSA-N
- SMILES
- O1C(C(C)=O)=CC2C(=O)C3=C(C(=O)C1=2)C=CC=C3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
2932.99.7000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-Acetylfuro-1,4-naphthoquinone Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Napabucasin is an inhibitor of cancer cell stemness. It reduces growth in a panel of cancer cells enriched for high stemness (IC
50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells.
In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.
Verwenden
Napabucasin is a cancer cell stemness inhibitor which attenuates the progression of prostate cancer.
2-Acetylfuro-1,4-naphthoquinone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Acetylfuro-1,4-naphthoquinone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 175)Lieferanten
83280-65-3()Verwandte Suche:
- 2-Acetylfuro-1,4-naphthoquinone
- 2-Acetylfuro-1,4-phthoquinone
- Napabucasin (BBI608)
- 2-acetylnaphtho[2,3-b]furan-4,9-quinone
- Naphtho[2,3-b]furan-4,9-dione, 2-acetyl-
- 2-acetylbenzo[f][1]benzofuran-4,9-dione
- 139057
- Napabucasin Impurity
- Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem
- BBI-606
- CS-945
- inhibit,BBI 608,BBI-608,Inhibitor,STAT,Napabucasin
- Cancer cell stemness inhibitor (Napabucasin)
- Cancer cell stemness inhibitor (Napabucasin), high-cancer cell inhibitor
- Napabucasin, 10 mM in DMSO
- Cancer Stemness Inhibitor, BBI608
- Napabucasin (BBI608) ，S7977
- Napabucasin
- Remimazolam besylate
- 83280-65-3
